24916-91-4 Usage
Description
IcoMethasone 21-Acetate, a derivative of 6-hydroxycorticosteroids Icomethasone (I164100), is a white solid with significant pharmaceutical applications. It is known for its potent anti-inflammatory and immunosuppressive properties, making it a valuable compound in the medical field.
Uses
Used in Pharmaceutical Industry:
IcoMethasone 21-Acetate is used as an anti-inflammatory agent for reducing inflammation and alleviating the symptoms of various conditions, such as allergies, skin disorders, and respiratory issues. Its potent anti-inflammatory action helps in managing the immune response and providing relief from inflammation-related discomfort.
IcoMethasone 21-Acetate is also used as an immunosuppressive agent for suppressing the immune system, particularly in cases where the body's immune response is causing harm, such as in autoimmune diseases or following organ transplantation. By dampening the immune response, it helps prevent organ rejection and allows for better management of autoimmune conditions.
Additionally, IcoMethasone 21-Acetate can be used in the development of drug delivery systems to enhance its bioavailability, targeting, and therapeutic outcomes. This may involve the use of various carriers, such as nanoparticles or liposomes, to improve the compound's delivery to specific sites of action and minimize potential side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 24916-91-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,9,1 and 6 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 24916-91:
(7*2)+(6*4)+(5*9)+(4*1)+(3*6)+(2*9)+(1*1)=124
124 % 10 = 4
So 24916-91-4 is a valid CAS Registry Number.
24916-91-4Relevant articles and documents
Improvements in corticosteroid 21-acetoxy-17α-hydroxy-16α-methyl-pregna-1,4,9(11)-triene-3,20-dione synthesis and its use as common intermediate in the synthesis of some impurities related to dexamethasone and mometasone
Das, Saibal Kumar,Dubey, Manoj Kumar,Buchhikonda, Ravinder
, p. 47 - 55 (2019/05/22)
There are quite substantial number of impurities related to dexamethasone or mometasone which cannot be made from respective Active Pharmaceutical Ingredients but from common intermediate 21-acetoxy-17α-hydroxy-16α-methyl-pregna-1,4,9(11)-triene-3,20-dione (12). As such, a robust and economical synthesis of this key intermediate is important for delivering a resilient and economically viable supply chain for these impurities. Therefore, it is critical to have a robust and economically viable process to synthesize the intermediate 12 in good yield and quality. We report here an improved synthesis of 12 and eight impurities related to dexamethasone and mometasone from this common intermediate.
