24928-30-1

Basic information

• Product Name: N-butyloctanamide
• CAS NO: 24928-30-1
• Molecular Formula: C₁₂H₂₅NO
• Molecular Weight: 199.333
• Mol File: 24928-30-1.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 281.3°C at 760 mmHg
• Flash Point: 167.4°C
• Density: 0.857g/cm³
• Vapor Pressure: 0.00359mmHg at 25°C
• Refractive Index: 1.439
• CAS DataBase Reference: N-butyloctanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-butyloctanamide(24928-30-1)
• EPA Substance Registry System: N-butyloctanamide(24928-30-1)

Safety Data

• Hazardous Substances Data: 24928-30-1(Hazardous Substances Data)

Upstream product

• 124-07-2 Octanoic acid 
• 109-73-9 N-butylamine 
• 107-10-8 propylamine 
• 111-64-8 n-octanoic acid chloride 
• 6166-47-8 octanoyl bromide 
• 1984-06-1 sodium caprylate 
• 156-54-7 sodium butyrate 
• 3858-78-4 n-butylamine hydrochloride 
• 106-32-1 octanoic acid ethyl ester 
• 1956-10-1 p-nitrophenyl-caprylate 

Relevant articles and documents

Repurposing the 3-Isocyanobutanoic Acid Adenylation Enzyme SfaB for Versatile Amidation and Thioesterification

Genome mining of microbial natural products enables chemists not only to discover the bioactive molecules with novel skeletons, but also to identify the enzymes that catalyze diverse chemical reactions. Exploring the substrate promiscuity and catalytic mechanism of those biosynthetic enzymes facilitates the development of potential biocatalysts. SfaB is an acyl adenylate-forming enzyme that adenylates a unique building block, 3-isocyanobutanoic acid, in the biosynthetic pathway of the diisonitrile natural product SF2768 produced by Streptomyces thioluteus, and this AMP-ligase was demonstrated to accept a broad range of short-chain fatty acids (SCFAs). Herein, we repurpose SfaB to catalyze amidation or thioesterification between those SCFAs and various amine or thiol nucleophiles, thereby providing an alternative enzymatic approach to prepare the corresponding amides and thioesters in vitro.

A catalyst-free, waste-less ethanol-based solvothermal synthesis of amides

A green, one-pot approach based on the solvothermal amidation of carboxylic acids with amines has been developed for the synthesis of diverse aliphatic and aromatic amides. It does not require the use of catalysts or coupling reagents and it occurs in the presence of ethanol that has been proved to have a key role in the process. The proposed strategy is also extendable to biologically active amides and could represent a low-cost and waste-less alternative to the common synthetic pathways.

One for Many: A Universal Reagent for Acylation Processes

This work describes acylation reactions facilitated by a type of heterocycle-based acyl transfer agent, 2-acyloxypyridazinone. Reactions of 2-acyloxypyridazinone with carboxylic acids yield mixed carbonic anhydride intermediates, which are reactive and could be coupled with a wide range of substrates including acids, amines, alcohols, and thiols. The wide substrate scope, ease of operation (no additive or catalyst), storage and handling stability, and atom-efficiency from recycling the heterocycle carrier make the reported acylating agent attractive for acylation-based coupling reactions.