249736-45-6

Basic information

• Product Name: N-[(1S)-1-(HydroxyMethyl)-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]-carbaMic Acid tert-Butyl Ester
• Synonyms: N-[(1S)-1-(HydroxyMethyl)-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]-carbaMic Acid tert-Butyl Ester;tert-butyl ((S)-1-hydroxy-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)carbamate;Carbamic acid, N-[(1S)-1-(hydroxymethyl)-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]-, 1,1-dimethylethyl ester;tert-butyl ((S)-1-hydroxy-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)carbamate(WXG01710)
• CAS NO: 249736-45-6
• Molecular Formula: C₁₂H₂₂N₂O₄
• Molecular Weight: 258.31408
• Product Categories: Amines, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 249736-45-6.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 480.0±20.0 °C(Predicted)
• Appearance: /
• Density: 1.132±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly, Sonicated)
• PKA: 11.87±0.46(Predicted)
• CAS DataBase Reference: N-[(1S)-1-(HydroxyMethyl)-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]-carbaMic Acid tert-Butyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(1S)-1-(HydroxyMethyl)-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]-carbaMic Acid tert-Butyl Ester(249736-45-6)
• EPA Substance Registry System: N-[(1S)-1-(HydroxyMethyl)-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]-carbaMic Acid tert-Butyl Ester(249736-45-6)

Safety Data

• Hazardous Substances Data: 249736-45-6(Hazardous Substances Data)

Usage

Description

N-[(1S)-1-(HydroxyMethyl)-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]-carbaMic Acid tert-Butyl Ester is a white solid compound with a complex chemical structure. It is characterized by its hydroxymethyl and pyrrolidinyl groups, which contribute to its unique properties and potential applications.

Uses

Used in Pharmaceutical Industry:
N-[(1S)-1-(HydroxyMethyl)-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]-carbaMic Acid tert-Butyl Ester is used as a key intermediate in the synthesis of Rhinovirus protease inhibitors for the treatment of viral infections, particularly the common cold caused by Rhinoviruses. Its chemical properties make it a suitable candidate for the development of antiviral drugs.
Used in Chemical Research:
As a complex organic molecule, N-[(1S)-1-(HydroxyMethyl)-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]-carbaMic Acid tert-Butyl Ester can also be used in chemical research to study its reactivity, stability, and potential applications in various chemical processes and reactions. This may lead to the discovery of new compounds and materials with diverse applications.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 6525-53-7 L-glutamic acid dimethyl ester 
• 56-86-0 L-glutamic acid 
• 328086-60-8 (2S)-2-(tert-butoxycarbonylamino)-3-[(3'S)-2'-oxo-3'-pyrrolidinyl]propanoic acid methy ester 
• 328086-58-4 (2S,4S)-2-(2-Amino-ethyl)-4-tert-butoxycarbonylamino-pentanedioic acid dimethyl ester 
• 328086-57-3 (2S,4S)-2-tert-butoxycarbonylamino-4-cyanomethyl-pentadioic acid dimethyl ester 
• 59279-60-6 dimethyl (2S)-2-[(tert-butoxycarbonyl)amino]pentanedioate 
• 112418-19-6 (R)-2-N-tert-butoxycarbonylamino-3-(tert-butyldimethylsilyloxy)propionic acid methyl ester 
• 95715-85-8 2-(tert-butoxycarbonylamino)-3-hydroxypropionic acid methyl ester 

Downstream Products

• 328086-54-0 (2E,4S)-4-(tert-butoxycarbonylamino)-5-[(3'S)-2'-oxo-3'-pyrrolidinyl]-2-pentenoic acid ethyl ester 
• 799270-24-9 (S,E)-ethyl 4-((2R,5S)-5-(tert-butoxycarbonylamino)-2-(4-fluorobenzyl)-6-methyl-4-oxoheptanamido)-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoate 
• 422323-15-7 (1''S,1''''S,3'''''S)-5-methylisoxazole-3-carboxylic acid (1'-{2''-(3''',4'''-difluorophenyl)-1''-[2''''-hydroxy-1''''-(2'''''-oxopyrrolidin-3'''''-ylmethyl)ethylcarbamoyl]ethyl}-2'-oxo-1',2'-dihydropyridin-3'-yl)amide 
• 328086-61-9 ethyl (S,E)-4-((tert-butoxycarbonyl)amino)-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoate 
• 869494-42-8 (E)-(S)-4-{(2R,4S,5S)-2-Benzyl-4-(tert-butyl-dimethyl-silanyloxy)-6-methyl-5-[(5-methyl-isoxazole-3-carbonyl)-amino]-heptanoylamino}-5-((S)-2-oxo-pyrrolidin-3-yl)-pent-2-enoic acid ethyl ester 

Relevant articles and documents

An efficient synthesis of a key intermediate for the preparation of the rhinovirus protease inhibitor AG7088 via asymmetric dianionic cyanomethylation of N-Boc-L-(+)-glutamic acid dimethyl ester

An efficient synthetic route to a key intermediate for the preparation of the rhinovirus protease inhibitor AG7088 has been developed employing a key asymmetric dianionic cyanomethylation of N-Boc-L-(+)-glutamic acid dimethyl ester. This methodology enables the preparation of this compound in kilogram quantities with an overall yield of 30%.

PROTEASE INHIBITORS FOR TREATMENT OR PREVENTION OF CORONAVIRUS DISEASE

Provided are protease inhibitor compounds that find use in treating or preventing coronavirus disease. In some embodiments, the coronavirus disease is COVID-19. Also provided are compositions and kits comprising the compounds, as well methods of using the

PEPTIDOMIMETICS FOR THE TREATMENT OF CORONAVIRUS AND PICORNAVIRUS INFECTIONS

Compounds, compositions and methods for preventing, treating or curing a coronavirus, picornavirus, and/or Hepeviridae virus infection in human subjects or other animal hosts. Specific viruses that can be treated include enteroviruses. In one embodiment, the compounds can be used to treat an infection with a severe acute respiratory syndrome virus, such as human coronavirus 229E, SARS, MERS, SARS-CoV-1 (OC43), and SARS-CoV- 2. In another embodiment, the methods are used to treat a patient co-infected with two or more of these viruses, or a combination of one or more of these viruses and norovirus.