249938-52-1 Usage
Description
Kaempferol-7-O-β-D-glucuronide is a glycosylated derivative of kaempferol, a plant flavonoid that contributes to the promotion of human health. It is characterized by the attachment of a β-D-glucuronide moiety to the kaempferol molecule, enhancing its bioavailability and biological activity.
Uses
Used in Pharmaceutical Applications:
Kaempferol-7-O-β-D-glucuronide is used as a bioactive compound for its potential health-promoting properties. It is derived from kaempferol, a flavonoid known to have beneficial effects on human health, and the addition of the glucuronide group may enhance its bioavailability and efficacy.
Used in Nutraceutical Applications:
In the nutraceutical industry, kaempferol-7-O-β-D-glucuronide is used as a dietary supplement for its potential health benefits. The compound is derived from natural sources and may contribute to the overall well-being of consumers by providing antioxidant and anti-inflammatory properties.
Used in Cosmetic Applications:
Kaempferol-7-O-β-D-glucuronide is used as an ingredient in the cosmetic industry for its potential skin health benefits. The compound may offer antioxidant protection and contribute to the maintenance of healthy skin by reducing inflammation and promoting skin regeneration.
Used in Functional Food Applications:
In the functional food industry, kaempferol-7-O-β-D-glucuronide is used as an additive for its potential to enhance the health benefits of food products. The compound may provide consumers with additional nutritional value and contribute to the prevention of various health conditions.
Used in Agricultural Applications:
Kaempferol-7-O-β-D-glucuronide can be used in the agricultural industry as a natural compound to improve the health and quality of crops. It may be applied as a supplement to enhance the growth and resistance of plants against various stressors, ultimately leading to higher crop yields and better quality produce.
Check Digit Verification of cas no
The CAS Registry Mumber 249938-52-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,4,9,9,3 and 8 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 249938-52:
(8*2)+(7*4)+(6*9)+(5*9)+(4*3)+(3*8)+(2*5)+(1*2)=191
191 % 10 = 1
So 249938-52-1 is a valid CAS Registry Number.
249938-52-1Relevant articles and documents
Enzymatic Synthesis of Bioactive O-Glucuronides Using Plant Glucuronosyltransferases
Yue, Tian,Chen, Ridao,Chen, Dawei,Liu, Jimei,Xie, Kebo,Dai, Jungui
, p. 6275 - 6284 (2019/06/13)
Many O-glucuronides exhibiting various pharmacological activities have been found in nature and in drug metabolism. The glucuronidation of bioactive natural products or drugs to generate glucuronides with better activity and druggability is important in drug discovery and research. In this study, by using two uridine diphosphate (UDP)-dependent glucuronosyltransferases (GATs, UGT88D4 and UGT88D7) from plants, we developed two glucuronidation approaches, pure enzyme catalysis in vitro and recombinant whole-cell catalysis in vivo, to efficiently synthesize bioactive O-glucuronides by the glucuronidation of natural products. In total, 14 O-glucuronides with different structures, including flavonoids, anthraquinones, coumarins, and lignans, were obtained, 7 of which were new compounds. Furthermore, one of the biosynthesized O-glucuronides, kaempferol-7-O-β-d-glucuronide (3a), potently inhibited protein tyrosine phosphatase (PTP) 1B with an IC50 value of 8.02 × 10-6 M. Some of the biosynthesized O-glucuronides also exhibited significant antioxidant activities.
