25024-96-8

Basic information

• Product Name: C₁₁H₁₇N₃O₂S*ClH
• Synonyms: C₁₁H₁₇N₃O₂S*ClH
• CAS NO: 25024-96-8
• Molecular Weight: 291.802
• Mol File: 25024-96-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₁H₁₇N₃O₂S*ClH(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₁H₁₇N₃O₂S*ClH(25024-96-8)
• EPA Substance Registry System: C₁₁H₁₇N₃O₂S*ClH(25024-96-8)

Safety Data

• Hazardous Substances Data: 25024-96-8(Hazardous Substances Data)

Upstream product

• 37073-18-0 N-(2-aminophenyl)methanesulfonamide 
• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 

Downstream Products

• 199105-19-6 1-(2-methanesulfonylamidophenyl)piperazine 

Relevant articles and documents

Synthesis and evaluation of a novel class Hsp90 inhibitors containing 1-phenylpiperazine scaffold

Previously, we identified 1-(2-(4-bromophenoxy)ethoxy)-3-(4-(2- methoxyphenyl)piperazin-1-yl)propan-2-ol (1) as a novel Hsp90 inhibitor with moderate activity through virtual screening. In this study, we report the optimization process of 1. A series of analogues containing the 1-phenylpiperazine core scaffold were synthesized and evaluated. The structure-activity relationships (SAR) for these compounds was also discussed for further molecular design. This effort afforded the most active inhibitor 13f with improved activity in not only target-based level, but also cell-based level compared with the original hit 1.