25045-82-3

Basic information

• Product Name: 6-NITROIMIDAZO[1,2-A]PYRIDINE
• Synonyms: 6-NITROIMIDAZO[1,2-A]PYRIDINE;IMidazo[1,2-a]pyridine, 6-nitro-
• CAS NO: 25045-82-3
• Molecular Formula: C7H5N3O2
• Molecular Weight: 163.13
• Mol File: 25045-82-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 229-231°
• Appearance: /
• Density: 1.496 g/cm³
• Refractive Index: 1.705
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.70±0.50(Predicted)
• CAS DataBase Reference: 6-NITROIMIDAZO[1,2-A]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-NITROIMIDAZO[1,2-A]PYRIDINE(25045-82-3)
• EPA Substance Registry System: 6-NITROIMIDAZO[1,2-A]PYRIDINE(25045-82-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 25045-82-3(Hazardous Substances Data)

Usage

General Description

6-Nitroimidazo[1,2-a]pyridine is a complex organic compound that belongs to the class of organic compounds known as imidazo[1,2-a]pyridines. As a nitrogen and oxygen-rich compound, it is identified by its unique molecular structure that incorporates both nitro group and imidazopyridine core. It showcases the characteristic properties of both nitro compounds and heterocyclic aromatic compounds. This includes its potential to participate in multiple chemical reactions, and possibly having applications for pharmacological uses. However, as with any chemical, appropriate safety measures must be taken while handling as it may present potential hazards or risks.

InChI:InChI=1/C7H5N3O2/c11-10(12)6-1-2-7-8-3-4-9(7)5-6/h1-5H

Upstream product

• 4214-76-0 5-nitro-pyridin-2-ylamine 
• 623-46-1 1,2-dichloro-2-ethoxyethane 
• 2032-35-1 Bromoacetaldehyde diethyl acetal 
• 107-20-0 2-chloroethanal 

Downstream Products

• 235106-53-3 imidazo[1,2-a]pyridin-6-ylamine 

Relevant articles and documents

From Synthetic Simplified Marine Metabolite Analogues to New Selective Allosteric Inhibitor of Aurora B Kinase

Significant inhibition of Aurora B was achieved by the synthesis of simplified fragments of benzosceptrins and oroidin belonging to the marine pyrrole-2-aminoimidazoles metabolites isolated from sponges. Evaluation of kinase inhibition enabled the discovery of a synthetically accessible rigid acetylenic structural analogue EL-228 (1), whose structure could be optimized into the potent CJ2-150 (37). Here we present the synthesis of new inhibitors of Aurora B kinase, which is an important target for cancer therapy through mitosis regulation. The biologically oriented synthesis yielded several nanomolar inhibitors. The optimized compound CJ2-150 (37) showed a non-ATP competitive allosteric mode of action in a mixed-type inhibition for Aurora B kinase. Molecular docking identified a probable binding mode in the allosteric site "F"and highlighted the key interactions with the protein. We describe the improvement of the inhibitory potency and specificity of the novel scaffold as well as the characterization of the mechanism of action.

Preparation process of 8-iodo-6-nitroimidazo[1,2-a]pyridine

The invention discloses a preparation process of 8-iodo-6-nitroimidazo[1,2-a]pyridine. The preparation process comprises the following step: by taking 2-amino-5-nitropyridine as a raw material, performing two-step reaction of cyclization and substitution to prepare the target product 8-iodo-6-nitroimidazo[1,2-a]pyridine. According to the route, the raw material is cheap and easily available, the 8-iodo product can be selectively obtained, the reaction conditions are mild, the process is simple to operate, and no organic metallic reagent causing severe environmental pollution is used, thereby being beneficial to environmental protection.