25057-77-6Relevant articles and documents
INHIBITORS OF WDR5 PROTEIN-PROTEIN BINDING
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, (2017/09/15)
The present application is directed to compounds of Formula I: compounds comprising these compounds and their uses, for example as medicaments for the treatment of diseases, disorders or conditions mediated or treatable by inhibition of binding between WDR5 protein and its binding partners.
DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP)
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Page/Page column 92, (2010/03/02)
A compound having the structure set forth in Formula (I) and Formula (II): wherein the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity.
Studies in Potential Filaricides: Part 20 - Synthesis of 1,4-Disubstituted Piperazines as Diethylcarbamazine Analogs
Charles, Elisabeth S.,Sharma, Satyavan
, p. 752 - 756 (2007/10/02)
A series of substituted 2,4-dimethylpiperazines (10-15), 1-benzyl-2-methylpiperazines (16-19), 1-substituted 3-methylpiperazines (20-25,27) and 1,4-disubstituted piperazines (28-34) have been synthesized starting from 1-benzyl-2-methylpiperazine (9) and 1