25085-83-0Relevant articles and documents
Asymmetric Photocatalytic C(sp3)-H Bond Addition to α-Substituted Acrylates
Dai, Zhen-Yao,Nong, Zhong-Sheng,Song, Shun,Wang, Pu-Sheng
supporting information, p. 3157 - 3161 (2021/05/05)
Asymmetric functionalization of inert C(sp3)-H bonds is a straightforward approach to realize versatile bond-forming events, allowing the precise assembly of molecular complexity with minimal functional manipulations. Here, we describe an asymmetric photocatalytic C(sp3)-H bond addition to α-substituted acrylates by using tetrabutylammonium decatungstate (TBADT) as a hydrogen atom transfer (HAT) photocatalyst and chiral phosphoric acid as a chiral proton-transfer shuttle. This protocol is supposed to occur via a radical/ionic relay process, including a TBADT-mediated HAT to cleave the inert C(sp3)-H bond, a 1,4-radical addition, a back hydrogen abstraction, and an enantioselective protonation. A variety of inert C-H bond patterns and α-substituted acrylates are well tolerated to enable the rapid synthesis of enantioenriched α-stereogenic esters from simple raw materials.
Polymeric depots for localization of agent to biological sites
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Page/Page column 64, (2019/04/26)
Provided herein are polymeric particles and compounds and processes that can be used to prepare polymer-based particles and methods of using those particles to localize or concentrate a subsequently delivered agent to an in vivo site.
Synthesis method of terminal olefin type compound
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Paragraph 0050; 0052; 0053, (2018/09/21)
The invention discloses a synthesis method of a terminal olefin type compound. The synthesis method comprises the following steps: taking a phosphorus ylide compound as a raw material and carbon dioxide as a C1 synthon in an organic solvent; reacting in the presence of a reducing agent to prepare the terminal olefin type compound, wherein the mole ratio of the phosphorus ylide compound to the reducing agent is 1 to (1 to 6) and the pressure of carbon dioxide is 1 to 3atm. The synthesis method disclosed by the invention has the advantages of convenience for operation, moderate conditions, widesubstrate applicable range and high efficiency; the defects in the prior art are filled; the synthesis method takes the carbon dioxide as synthon and carbon dioxide can be effectively absorbed so thata greenhouse effect is effectively prevented.