25109-54-0Relevant articles and documents
The synthesis of potential Neramexane metabolites: Cis- and trans-3-amino-1,3,5,5-tetramethylcyclohexanecarboxylic acids
Trifanova, Dina,Trifonova, Marija,Jirgensons, Aigars,Kauss, Valerjans,Pugovich, Osvalds,Kalvinsh, Ivars,Quack, Guenter
, p. 8145 - 8147 (2004)
A seven step synthetic route toward potential Neramexane metabolites cis- and trans-3-amino-1,3,5,5-tetramethylcyclohexanecarboxylic acids, cis-1 and trans-1, has been developed from isophorone. The synthetic procedure represents a useful method for the preparation of γ-amino acids with both amino and carboxyl groups situated at tertiary carbon atoms.
EFFECTS OF LEWIS ACIDS ON HIGHER ORDER, MIXED CUPRATE COUPLINGS
Lipshutz, Bruce H.,Parker, David A.,Kozlowski, Joseph A.,Nguyen, Sam L.
, p. 5959 - 5962 (1984)
The presence of BF3*Et2O in reactions of R2Cu(CN)Li2 and RT(2-thienyl)Cu(CN)Li2 with epoxides and α,β-unsaturated ketones leads to dramatic enhancements in reaction rates and/or product yields relative to those observed in the absence of this L
Synthesis of Cyclohexanones through a Catalytic Cationic Cyclization of Alkynols or Enynes
Alonso, Pedro,Fontaneda, Raquel,Pardo, Pilar,Fa?anás, Francisco J.,Rodríguez, Félix
supporting information, p. 1659 - 1662 (2018/03/23)
A novel procedure for the synthesis of cyclohexanones from alkynol or enyne derivatives through a cationic cyclization has been developed. The key points to obtain the six-membered ring derivatives are the use of starting materials containing a terminal alkyne, the use of tetrafluoroboric acid as a promoter of the cationic cyclization, and the appropriate selection of 1,1,1,3,3,3-hexafluoropropan-2-ol (HFIP) as solvent. This strategy can be extended to the biomimetic cationic cyclization of several terpene-derived polyenynes.
Nickel Catalysed 1,4-Addition of Aryl Groups to Enones Using Aryldialkylaluminium Compounds
Westermann, Juergen,Imbery, Ute,Nguyen, Anh Thu,Nickisch, Klaus
, p. 293 - 298 (2007/10/03)
The transmetallation of arylmagnesium halides or aryllithium with Me2AlCl results in the formation of aryldimethylaluminium compounds.These arylaluminium compounds are useful reagents for conjugate additions to enones in the presence of Ni(acac)2 as a catalyst. 3-Aryl ketones are obtained in good yields in these catalytic reactions.Starting from the 3-oxo-Δ1,4-steroids this method gives access to 1α-arylsteroids. - Keywords: conjugate addition; enones; steroids