2511-09-3 Usage
Description
Ethyl phenylphosphinate, an organophosphorous compound, is characterized by its ability to undergo regioselective Markovnikov addition reactions with terminal alkynes in the presence of a palladium-1,2-bis(diphenylphosphino)ethane complex catalyst. It is also known as a photodecomposition product of Inezin (S-benzyl O-ethyl phenylphosphonothiolate) upon ultraviolet irradiation. Ethyl phenylphosphinate can be synthesized through the reaction of phosphinic acid with ethyl chloroformate in the presence of pyridine, and its ethylation using ethyl trimethylsilyl phenylphosphonite or the corresponding trimethylstannyl ester has been documented. Additionally, its free-radical addition to ethylene is reported to proceed with the retention of configuration.
Uses
Used in Chemical Synthesis:
Ethyl phenylphosphinate is used as a key intermediate in the preparation of various diethyl imidazol-2-yl-(amino) methylphosphonates and phosphinates. These compounds have potential applications in different fields, such as pharmaceuticals and materials science.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, ethyl phenylphosphinate is used as a starting material for the synthesis of diethyl imidazol-2-yl-methyl(N-butylamino)phosphonate diethyl ester, imidazol-2-yl-methyl(N-benzylamino)phosphonate diethyl ester, imidazol-2-yl-methyl(N-butylamino)phenylphosphinate ethyl ester, and imidazol-2-yl-methyl(N-benzylamino)phenylphosphinate ethyl ester. These compounds may have potential therapeutic applications due to their unique chemical structures and properties.
Used in Materials Science:
Ethyl phenylphosphinate may also find applications in the field of materials science, where its unique chemical properties can be exploited to develop new materials with specific characteristics, such as improved stability or reactivity.
Check Digit Verification of cas no
The CAS Registry Mumber 2511-09-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,5,1 and 1 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 2511-09:
(6*2)+(5*5)+(4*1)+(3*1)+(2*0)+(1*9)=53
53 % 10 = 3
So 2511-09-3 is a valid CAS Registry Number.
InChI:InChI=1/C8H11O2P/c1-2-10-11(9)8-6-4-3-5-7-8/h3-7,11H,2H2,1H3
2511-09-3Relevant articles and documents
Palladium-Catalyzed Domino Cyclization/Phosphorylation of gem-Dibromoolefins with P(O)H Compounds: Synthesis of Phosphorylated Heteroaromatics
Chen, Chen,Ding, Jie,Liu, Liying,Huang, Yujie,Zhu, Bolin
supporting information, p. 200 - 205 (2021/10/29)
We presented a palladium-catalyzed domino cyclization/phosphorylation of gem-dibromoolefins, which utilize H-phosphinates and secondary phosphine oxides as the phosphine sources, respectively. A variety of phosphorylated heteroaromatics were obtained in m
A facile and practical preparation ofP-chiral phosphine oxides
Xu, Ronghua,Gao, Zhenhua,Yu, Yiteng,Tang, Yehua,Tian, Duanshuai,Chen, Tian,Chen, Yibing,Xu, Guangqing,Shi, Enxue,Tang, Wenjun
supporting information, p. 3335 - 3338 (2021/04/07)
A practical and cost-effective synthetic method ofP-chiral diarylalkyl, aryldialkyl, and triaryl phosphine oxides by using readily available chiral diphenyl-2-pyrrolidinemethanol as the auxiliary is developed. The long-standing racemization issue during s
Visible-light-induced ligand to metal charge transfer excitation enabled phosphorylation of aryl halides
Hou, Hong,Zhou, Bing,Wang, Jiawei,Sun, Duhao,Yu, Huaguang,Chen, Xiaoyun,Han, Ying,Shi, Yaocheng,Yan, Chaoguo,Zhu, Shaoqun
supporting information, p. 5702 - 5705 (2021/06/16)
We herein described a visible light induced nickel(II)-catalyzed cross-coupling of secondary phosphine oxides with aryl halides. The Ni(I)species and chlorine atom radical Cl˙ were generatedviathe ligand to metal charge transfer (LMCT) process of the NiCl2(PPh3)2, which allows nickel(IV)-phosphorus speciesin situformation, giving various tertiary phosphine oxides under photocatalyst-free conditions.
