25122-41-2 Usage
Description
Clobetasol, also known as Clobetasol Propionate, is a potent topical corticosteroid belonging to the class of glucocorticoids. It is characterized by its anti-inflammatory properties and is used to treat various skin disorders. Clobetasol is a 3-oxo-Δ1,Δ4-steroid with hydroxy groups at the 11β and 17α positions, fluorine at position 9, and a chlorine substituent at position 21. It is typically administered as its 17α-propionate ester. The chemical properties of Clobetasol include being a white to off-white solid.
Uses
Used in Pharmaceutical Industry:
Clobetasol is used as a topical corticosteroid for its anti-inflammatory properties. It is effective in treating various skin disorders such as eczema, psoriasis, and other inflammatory skin conditions. The glucocorticoid nature of Clobetasol helps to reduce inflammation, itching, and redness associated with these skin conditions.
Brand Names:
Clobetasol is available under several brand names, including Clobex (Galderma), Embeline (Healthpoint), Olux (Connetics), and Temovate (Altana). These products are formulated as creams, ointments, or lotions for topical application to the affected skin areas.
Originator
Dermovate,Glaxo,UK,1973
Manufacturing Process
A solution of betamethasone 21-methanesulfonate (4 g) in dimethylformamide
(25 ml) was treated with lithium chloride (4 g) and the mixture heated on the
steam bath for 30 minutes. Dilution with water gave the crude product which
was recrystallized to afford the title compound, MP 226°C.
Clobetasol is usually converted to the propionate as the useful form by
reaction with propionic anhydride.
Therapeutic Function
Corticosteroid, Antiinflammatory
Check Digit Verification of cas no
The CAS Registry Mumber 25122-41-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,5,1,2 and 2 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 25122-41:
(7*2)+(6*5)+(5*1)+(4*2)+(3*2)+(2*4)+(1*1)=72
72 % 10 = 2
So 25122-41-2 is a valid CAS Registry Number.
InChI:InChI=1/C22H28ClFO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,24)17(26)10-20(16,3)22(12,28)18(27)11-23/h6-7,9,12,15-17,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1
25122-41-2Relevant articles and documents
α-Keto Mesylate: A Reactive, Thiol-Specific Functional Group
Simons, Stoney S.,Pons, Michel,Johnson, David F.
, p. 3084 - 3088 (2007/10/02)
A systematic study of the reactivity of α-keto mesylates with various nucleophiles (i.e., carboxylate, -OH, imidazole, -NH2, thiol acid anion, and -SH) under mildly basic conditions is reported. α-Keto mesylates do not react with imidazole or hydroxyl groups, react extremely slowly (if at all) with carboxylate and primary amines, and react several thousand times faster with thiols and thiol acid anions.The very rapid reaction with thiols occurs only with the dissociated thiolate anion.The addition of a β-hydroxyl group to α-keto mesylates accelerates the reaction with thiolate anions by a factor of 3-12 in acetone but has no effect on reactions run in dimethylformamide. α-Keto mesylates exhibit the same selectivity for thiolate anions, as compared to amines, as do α-keto chlorides.In view of this reactivity and selectivity, the α-keto mesylate appears to be a promising functional group for the electrophilic affinity labeling of biological macromolecules in weakly basic solutions.
