251316-94-6 Usage
Description
FMOC-TRP-PRO-OH is a chemical compound consisting of three amino acids: tryptophan, proline, and a hydroxyl group, with an additional FMOC (9-fluorenylmethoxycarbonyl) protective group. FMOC-TRP-PRO-OH is integral in peptide synthesis, as the FMOC group shields the amino acids during the process. Tryptophan, an essential amino acid, plays a crucial role in protein synthesis and various biological functions, while proline, a non-essential amino acid, contributes to protein structure and function. The hydroxyl group enhances the molecule's polarity, broadening its potential applications.
Uses
Used in Pharmaceutical Industry:
FMOC-TRP-PRO-OH is used as a building block for the synthesis of peptides and proteins, facilitating the development of new drugs and therapeutic agents. Its role in creating specific protein structures makes it valuable for research and drug design.
Used in Research and Development:
FMOC-TRP-PRO-OH is used as a research tool for studying the properties and interactions of amino acids, peptides, and proteins. Its unique composition allows scientists to explore its potential in various biological processes and applications.
Used in Chemical Synthesis:
FMOC-TRP-PRO-OH is used as an intermediate in the synthesis of various chemical compounds, taking advantage of its reactive groups and amino acid composition for creating complex molecules with specific functions.
Used in Biochemical Analysis:
FMOC-TRP-PRO-OH is used as a reagent in biochemical assays and tests, helping to analyze and understand the behavior of proteins and peptides in different conditions.
Used in Peptide Drug Development:
FMOC-TRP-PRO-OH is used as a key component in the development of peptide-based drugs, leveraging its amino acid sequence to target specific biological pathways and therapeutic effects.
Check Digit Verification of cas no
The CAS Registry Mumber 251316-94-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,5,1,3,1 and 6 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 251316-94:
(8*2)+(7*5)+(6*1)+(5*3)+(4*1)+(3*6)+(2*9)+(1*4)=116
116 % 10 = 6
So 251316-94-6 is a valid CAS Registry Number.
251316-94-6Relevant articles and documents
Functional identification and structure determination of two novel prolidases from cog1228 in the amidohydrolase superfamily
Xiang, Dao Feng,Patskovsky, Yury,Xu, Chengfu,Fedorov, Alexander A.,Fedorov, Elena V.,Sisco, Abby A.,Sauder, J. Michael,Burley, Stephen K.,Almo, Steven C.,Raushel, Frank M.
experimental part, p. 6791 - 6803 (2011/05/05)
Two uncharacterized enzymes from the amidohydrolase superfamily belonging to cog1228 were cloned, expressed, and purified to homogeneity. The two proteins, Sgx9260c (gi|44242006) and Sgx9260b (gi|44479596), were derived from environmental DNA samples originating from the Sargasso Sea. The catalytic function and substrate profiles for Sgx9260c and Sgx9260b were determined using a comprehensive library of dipeptides and N-acyl derivative of l-amino acids. Sgx9260c catalyzes the hydrolysis of Gly-l-Pro, l-Ala-l-Pro, and N-acyl derivatives of l-Pro. The best substrate identified to date is N-acetyl-l-Pro with a value of kcat/Km of 3 × 105 M -1 s-1. Sgx9260b catalyzes the hydrolysis of l-hydrophobic l-Pro dipeptides and N-acyl derivatives of l-Pro. The best substrate identified to date is N-propionyl-l-Pro with a value of kcat/Km of 1 × 105 M-1 s-1. Three-dimensional structures of both proteins were determined by X-ray diffraction methods (PDB codes 3MKV and 3FEQ). These proteins fold as distorted (β/α) 8-barrels with two divalent cations in the active site. The structure of Sgx9260c was also determined as a complex with the N-methylphosphonate derivative of l-Pro (PDB code 3N2C). In this structure the phosphonate moiety bridges the binuclear metal center, and one oxygen atom interacts with His-140. The α-carboxylate of the inhibitor interacts with Tyr-231. The proline side chain occupies a small substrate binding cavity formed by residues contributed from the loop that follows β-strand 7 within the (β/α)8-barrel. A total of 38 other proteins from cog1228 are predicted to have the same substrate profile based on conservation of the substrate binding residues. The structure of an evolutionarily related protein, Cc2672 from Caulobacter crecentus, was determined as a complex with the N-methylphosphonate derivative of l-arginine (PDB code 3MTW).
