25143-76-4

Basic information

• Product Name: Cyclohexanol, 4-(1,1-dimethylethyl)-1-ethyl-, trans-
• CAS NO: 25143-76-4
• Molecular Formula: C12H24O
• Molecular Weight: 184.322
• Mol File: 25143-76-4.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Cyclohexanol, 4-(1,1-dimethylethyl)-1-ethyl-, trans-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanol, 4-(1,1-dimethylethyl)-1-ethyl-, trans-(25143-76-4)
• EPA Substance Registry System: Cyclohexanol, 4-(1,1-dimethylethyl)-1-ethyl-, trans-(25143-76-4)

Safety Data

• Hazardous Substances Data: 25143-76-4(Hazardous Substances Data)

Upstream product

• 98-53-3 4-tercbutyl-cyclohexanone 
• 6555-58-4 1β-Acetyl-4β-t-butyl-1α-cyclohexanol 
• 94718-84-0 4-tert-Butyl-1-(1-methylselanyl-ethyl)-cyclohexanol 
• 72091-16-8 cis-7-tert-butyl-1-oxaspiro<3.5>nonane 
• 2397-68-4 sodium tetraethylaluminate 
• 6689-15-2 methylenebis(diethylalane) 
• 925-90-6 ethylmagnesium bromide 
• 6556-05-4 1-ethynyl-t-4-tert-butylcyclohexan-r-1-ol 

Relevant articles and documents

Electroorganic Chemistry. 140. Electroreductively Intra- and Intermolecular Couplings of Ketones with Nitriles

Electroreduction of γ- and δ-cyano ketones in i-PrOH with Sn cathode gave α-hydroxy ketones and their dehydroxylated ketones as the intramolecularly coupled products.Guaiazulene, (-)-valeranone, polyquinanes, dihydrojasmone, methyl dihydrojasmonate, and rosaprostol have been synthesized by utilizing this electroreductive intramolecular coupling of γ- and δ-cyano ketones in one of the key steps.Similarly, electroreduction of a mixture of ketone and nitrile gave the corresponding intermolecularly coupled product.The product obtained by the electroreductive intermolecular coupling of (+)-dihydrocarvone with acetonitrile has been found to be the precursor of an effective chiral ligand for the enantioselective addition of diethylzinc to aldehydes.

Amphiphilic Reactions by Means of Exceptionally Bulky Organoaluminum Reagents. Rational Approach for Obtaining Unusual Equatorial, Anti-Cram, and 1,4 Selectivity in Carbonyl Alkylation

Exceptionally bulky, oxygenophilic organoaluminum reagents, methylaluminum bis(2,6-di-tert-4-alkylphenoxide) (MAD and MAT), have been successfully utilized for stereoselective activation of carbonyl moiety.Combination of MAD or MAT with carbon nucleophiles such as organolithiums or Grignard reagents generates a new amphiphilic reaction system in which the alkylation may be interpreted as the nucleophilic addition of a reactive organometallic compound to an electrophilically activated carbonyl substrate in order to account for the regio- and stereochemical consequences.In contrast to the ordinary alkylations, the amphilic alkylation disclosed herein would be categorized into the new, yet unexplored class of alkylation that exhibits high chemoselectivity to carbonyl compounds, and more significantly it allows excellent equatorial and anti-Cram selectivity in carbonyl alkylations, hitherto difficult by the existing methodologies.Further, unusual conjugate addition of organolithium reagents to α,β-unsaturated carbonyl compounds has been accomplished by using the amphiphilic reaction system.

Methylaluminum Bis(2,6-di-tert-butyl-4-alkylphenoxide). A New Reagent for Obtaining Unusual Equatorial and Anti-Cram Selectivity in Carbonyl Alkylation

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