25152-20-9

Basic information

• Product Name: 5'-AMINO-5'-DEOXYTHYMIDINE
• Synonyms: 5'-AMINO-5'-DEOXYTHYMIDINE;5'-Amino-5'-deoxy-D-thymidine
• CAS NO: 25152-20-9
• Molecular Formula: C₁₀H₁₅N₃O₄
• Molecular Weight: 241.24
• Product Categories: Biochemicals and Reagents;Nucleoside Analogs;Nucleosides, Nucleotides, Oligonucleotides
• Mol File: 25152-20-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.394 g/cm³
• Storage Temp.: 2-8°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 5'-AMINO-5'-DEOXYTHYMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-AMINO-5'-DEOXYTHYMIDINE(25152-20-9)
• EPA Substance Registry System: 5'-AMINO-5'-DEOXYTHYMIDINE(25152-20-9)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 25152-20-9(Hazardous Substances Data)

Usage

Description

5'-AMINO-5'-DEOXYTHYMIDINE, also known as 5'-Amino-5'-deoxy-2'-deoxythymidine or 5'-Amino-5'-deoxythymidine (5'-ADT), is a synthetic nucleoside analog with potential applications in the medical field. It is characterized by the presence of an amino group at the 5' position of the deoxythymidine molecule, which distinguishes it from the naturally occurring thymidine.

Uses

Used in Pharmaceutical Industry:
5'-AMINO-5'-DEOXYTHYMIDINE is used as a pharmaceutical compound for the development of novel therapeutic agents targeting anti-angiogenic resistant cancer. Its unique structure allows it to potentially interfere with cancer cell growth and proliferation by disrupting essential cellular processes, such as DNA replication and repair.
Used in Cancer Treatment:
5'-AMINO-5'-DEOXYTHYMIDINE is used as an anti-cancer agent in the treatment of anti-angiogenic resistant cancer. It may help overcome resistance to current anti-angiogenic therapies by targeting specific molecular pathways involved in cancer progression and angiogenesis, the process by which new blood vessels form to supply nutrients to tumors.

Downstream Products

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• 90414-52-1 5'-deoxy-5'-<<4-<(4-nitrobenzyl)oxy>phenoxy>acetamido>thymidine 
• 89196-54-3 5'-<<4-(bromoacetyl)benzoyl>amino>-5'-deoxythymidine 
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Relevant articles and documents

SYNTHESIS AND CHARACTERIZATION OF A CARBAMATE-LINKED OLIGONUCLEOSIDE

Reaction of 5'-O-dimethoxytritylthymidine with 1,1'-carbonyldiimidazole gave the 3'-O-carbonylimidazolide, which was condensed in high yield with 5'-amino-5'-deoxythymidine to produce a dinucleoside containing a 3'-O-5'-N-carbamoyl linkage.Four repetitions of carbonyl imidazolide formation and condensation produced a carbamate-linked hexamer.Hydrolytic and thermal denaturation studies did not indicate the presence of intramolecular base stacking.