25163-93-3

Basic information

• Product Name: 8-PHENYL-1,4-DIOXASPIRO[4,5]DECANE
• Synonyms: 8-PHENYL-1,4-DIOXASPIRO[4,5]DECANE
• CAS NO: 25163-93-3
• Molecular Formula: C₁₄H₁₈O₂
• Molecular Weight: 218.29
• Mol File: 25163-93-3.mol
• Article Data: 8

Chemical Properties

• Melting Point: 54-56 °C
• Boiling Point: 334.1°C at 760 mmHg
• Flash Point: 168.9°C
• Appearance: /
• Density: 1.1g/cm³
• Vapor Pressure: 0.000253mmHg at 25°C
• Refractive Index: 1.552
• CAS DataBase Reference: 8-PHENYL-1,4-DIOXASPIRO[4,5]DECANE(CAS DataBase Reference)
• NIST Chemistry Reference: 8-PHENYL-1,4-DIOXASPIRO[4,5]DECANE(25163-93-3)
• EPA Substance Registry System: 8-PHENYL-1,4-DIOXASPIRO[4,5]DECANE(25163-93-3)

Safety Data

• Hazardous Substances Data: 25163-93-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H18O2/c1-2-4-12(5-3-1)13-6-8-14(9-7-13)15-10-11-16-14/h1-5,13H,6-11H2

Upstream product

• 4894-75-1 1-phenyl-4-cyclohexanone 
• 107-21-1 ethylene glycol 
• 60-29-7 diethyl ether 
• 51509-98-9 8-Phenyl-1,4-dioxaspiro<4.5>decan-8-carbonitril 
• 7664-41-7 ammonia 
• 64-17-5 ethanol 
• 108-88-3 toluene 
• 149507-27-7 4-(4-cyanophenyl)cyclohexanone-ethylene ketal 
• 22428-87-1 4,4-ethylenedioxycyclohexan-1-ol 
• 24388-23-6 2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole 
• 108-86-1 bromobenzene 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 170011-47-9 1,4-dioxaspiro[4.5]dec-7-en-8-yl trifluoromethanesulfonate 
• 724707-89-5 4-phenylcyclohex-3-en-1-one ethylene glycol ketal 

Downstream Products

• 139021-96-8 9-phenyl-1,5-dithia-spiro[5.5]undecane 
• 4894-75-1 1-phenyl-4-cyclohexanone 

Relevant articles and documents

Merging Halogen-Atom Transfer (XAT) and Copper Catalysis for the Modular Suzuki-Miyaura-Type Cross-Coupling of Alkyl Iodides and Organoborons

We report here a mechanistically distinct approach to achieve Suzuki-Miyaura-type cross-couplings between alkyl iodides and aryl organoborons. This process requires a copper catalyst but, in contrast with previous approaches based on palladium and nickel

Electrochemically Enabled, Nickel-Catalyzed Dehydroxylative Cross-Coupling of Alcohols with Aryl Halides

As alcohols are ubiquitous throughout chemical science, this functional group represents a highly attractive starting material for forging new C-C bonds. Here, we demonstrate that the combination of anodic preparation of the alkoxy triphenylphosphonium ion and nickel-catalyzed cathodic reductive cross-coupling provides an efficient method to construct C(sp2)-C(sp3) bonds, in which free alcohols and aryl bromides - both readily available chemicals - can be directly used as coupling partners. This nickel-catalyzed paired electrolysis reaction features a broad substrate scope bearing a wide gamut of functionalities, which was illustrated by the late-stage arylation of several structurally complex natural products and pharmaceuticals.

Overcoming hERG activity in the discovery of a series of 4-azetidinyl-1-aryl-cyclohexanes as CCR2 antagonists

A series of 4-azetidinyl-1-aryl-cyclohexanes as potent CCR2 antagonists with high selectivity over activity for the hERG potassium channel is discovered through divergent SARs of CCR2 and hERG.