251635-29-7Relevant articles and documents
TETRAHYDROINDOLONE DERIVATIVES AS GABAAALPHA5 LIGANDS FOR ENHANCING COGNITION
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, (2008/06/13)
Compounds according to Formula (I) or a pharmaceutically acceptable salt thereof are GABA-A Alpha 5 ligands useful for enhancing cognition: where A is C 1-6alkyl, C 2-6alkenyl, C 2-6alkynyl, C 3-6cycloalkyl, arylC 1-6alkyl, or aryl wherein the aryl group is optionally substituted by halogen, C 1-6alkyl, CF 3, CN, NO 2 or NH 2, NR 1R 10, S(O) pR 1, heteroarylC 1-6alkyl or heteroaryl where heteroaryl is a 5-or 6-membered heteroaromatic ring as defined for B; and B is phenyl or a 5-membered ring having one or two unsaturations containing 1, 2, 3, or 4 heteroatoms chosen from O, N and S provided that not more than one heteroatom is other than N, a 6-membered heteroaromatic ring containing 1, 2, 3 or 4 nitrogen atoms, each of which rings is optionally substituted by one or more substituents.