25166-14-7

Basic information

• Product Name: 3-hydroxyhydnocarpin-D
• Synonyms: 3-hydroxyhydnocarpin-D
• CAS NO: 25166-14-7
• Molecular Weight: 480.428
• Mol File: 25166-14-7.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 3-hydroxyhydnocarpin-D(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxyhydnocarpin-D(25166-14-7)
• EPA Substance Registry System: 3-hydroxyhydnocarpin-D(25166-14-7)

Safety Data

• Hazardous Substances Data: 25166-14-7(Hazardous Substances Data)

Upstream product

• 22888-70-6 silibinin 
• 802918-57-6 silybin 

Relevant articles and documents

Investigations into neuroprotectivity, stability, and water solubility of 7-O-cinnamoylsilibinin, its hemisuccinate and dehydro derivatives

Derivatives of the recently described potent neuroprotective 7-O-cinnamoylsilibinin ester were prepared: its hemisuccinate to improve water solubility and the dehydrosilibinin ester that was shown to form in assay media to investigate its role in overall neuroprotective effects. 7-O-Cinnamoyl-2,3-dehydrosilibinin is less neuroprotective than 7-O-cinnamoylsilibinin in a murine hippocampal cell line (HT-22) and we conclude that the dehydrosilibinin derivatives are not the actual carriers of neuroprotective properties, at least in the assay applied. Solubility of the test compounds was determined in shake-flask experiments and the ester's solubility was greatly improved by introduction of a hemisuccinate at the 23-position of silibinin. Time–stability curves in assay media were recorded. The hemisuccinate ester did not act as a prodrug to release 7-O-cinnamoylsilibinin but is the second ester bond to be cleaved. Nevertheless, it still exhibits significant neuroprotection. Therefore, its greatly increased solubility might effectively counterbalance lower in vitro neuroprotection.

Continuous flow microchannel synthesis process of flavonoid compounds

The invention provides a continuous flow microchannel synthesis process of flavonoid compounds. According to the process, hesperidin and iodine elementary substance are used as raw materials and react in a continuous flow microchannel reactor in the presence of a reaction solvent to synthesize the flavonoid compound as shown in a formula A. Compared with a traditional kettle-type preparation process, the process disclosed by the invention has the advantages that the preparation time is obviously shortened, and the conversion rate of raw materials and the yield of products are obviously improved; and especially, when the diosmin is prepared under optimal process conditions of continuous flow microchannel synthesis, the conversion rate of the raw material hesperidin is as high as 96.48%, and the yield of the product diosmin is as high as 81.96%. The continuous flow micro-channel synthesis process provided by the invention is beneficial to realizing safe, efficient and rapid industrial production of flavonoid compounds, and has a wide application prospect.

Base-catalyzed oxidation of silybin and isosilybin into 2,3-dehydro derivatives

The base-catalyzed oxidation of the flavonolignans, silybin, and isosilybin into the corresponding 2,3-dehydro derivatives has been studied and optimized. Various bases, solvents, and reaction conditions were tested to achieve the best yields. The influence of water on the course of the reaction was also observed. It was found that this oxidation reaction was probably based on the disproportionation of the (iso)silybin (or some intermediate) molecule, as the reaction also proceeds in the absence of oxygen. We report here for the first time the preparation of optically pure 2,3-dehydroisosilybins A and B.