2518-42-5Relevant articles and documents
Studies in Nickel(IV) Chemistry. Part 3. Kinetics of Metal(II) Ion-mediated Acid Decomposition of Tris(dimethylglyoximato)-nickelate(IV) in Aqueous Medium
Neogi, Gautam,Acharya, Sridhara,Panda, Rama Krushna,Ramaswamy, Dorai
, p. 1239 - 1246 (1983)
The kinetics of metal(II) ion-mediated acid decomposition of tris(dimethylglyoximato)nickelate(IV), 2-, with concomitant intramolecular electron transfer to produce and Ni2+(aq) have been studied at 35 deg C and ionic strength 0.57 mol dm-3 in aqueous medium in the range 3.6 IV complex and MII(aq) (M=Cu, Zn, or Ni) present in the medium.While the rate-determining steps in the reactions with CuII are envisaged to involve acid decomposition of the adduct formed in addition to proton-assisted decomposition of the NiIV complex, those in the reactions with ZnII and NiII proceed essentially by routes parallel to the proton-assisted decomposition.U.v.-visible spectral changes in the NiIV-CuII reaction indicate the formation of the 1:1 adduct.
Oxidation of: O -dioxime by (diacetoxyiodo)benzene: Green and mild access to furoxans
He, Chunlin,Pang, Siping,Zhang, Qi,Zhang, Xun,Zhao, Cheng
supporting information, p. 1489 - 1493 (2022/01/31)
Furoxan has been widely used in the field of high energy density materials because of its excellent properties such as high density, high standard enthalpy of formation and high nitrogen content. However, its existing synthesis methods are still restricted by the problems of difficult substrate preparation and manual handling of hazardous reagents. Herein, we disclosed a mild oxidation strategy to efficiently obtain furoxan derivatives starting from readily available o-dioxime substrates. This reaction features high functional group tolerance and easy scale-up, and has excellent regioselectivity for specific nonsymmetric o-dioximes. This method greatly reduces the safety risk and simplifies the operation process, and means that diversified furoxan derivatives can be easily accessed, thus paving the way for the wide application of furoxan derivatives. This journal is
Synthesis of functionalized 2-isoxazolines as three-dimensional fragments for fragment-based drug discovery
Tran, Ngoc Chau,Dhondt, Heleen,Flipo, Marion,Deprez, Benoit,Willand, Nicolas
supporting information, p. 4119 - 4123 (2015/08/03)
Abstract The design of new sp3 and spiro-enriched fragments has been achieved from 1,3-dipolar cycloaddition between alkenes and chloro-oximes. The selection of reagents was performed to afford a panel of 2-isoxazoline-containing fragments that show desirable three dimensional (3D) characteristics to allow the probing of biologically-relevant chemical space. Principal moments of inertia (PMI) were calculated to evaluate the 3D diversity. The resulting 3D fragments with suitable physicochemical properties, especially a good solubility, will be used to improve the hit rate of our fragment-based screening.
Copper(II)-mediated oxidation of 1,2-dioxime to furoxan
Das, Oindrila,Paria, Sayantan,Paine, Tapan Kanti
experimental part, p. 5924 - 5927 (2009/04/05)
1,2-Dioximes undergo oxidative transformation mediated by copper(II) ions in acetonitrile to form the corresponding furoxans in high yields. A series of 1,2-dioximes including aliphatic, aromatic, and heterocyclic dioximes were oxidized using these mild c
