25185-95-9

Basic information

• Product Name: 2,6-Dichlorobenzaldoxime
• Synonyms: 2,6-DICHLOROBENZALDOXIME;2,6-DICHLOROBENZALOXIME;TIMTEC-BB SBB008012;2,6-dichloro-benzaldehydoxime;2,6-dichlorobenzyloxime;Benzaldehyde, 2,6-dichloro-, oxime;2,6-DICHLOROBENZALDOXIM;2.6-Dichlorobenzyloxim
• CAS NO: 25185-95-9
• Molecular Formula: C₇H₅Cl₂NO
• Molecular Weight: 190.03
• EINECS: 246-720-0
• Product Categories: Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes
• Mol File: 25185-95-9.mol
• Article Data: 52

Chemical Properties

• Melting Point: 147 °C
• Boiling Point: 280.4 °C at 760 mmHg
• Flash Point: 123.4 °C
• Appearance: white crystal powder
• Density: 1.38 g/cm³
• Vapor Pressure: 0.0018mmHg at 25°C
• Refractive Index: 1.575
• BRN: 2046662
• CAS DataBase Reference: 2,6-Dichlorobenzaldoxime(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Dichlorobenzaldoxime(25185-95-9)
• EPA Substance Registry System: 2,6-Dichlorobenzaldoxime(25185-95-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-26-36/37/39
• TSCA: Yes
• HazardClass: IRRITANT
• Hazardous Substances Data: 25185-95-9(Hazardous Substances Data)

Usage

General Description

2,6-Dichlorobenzaldoxime is a chemical compound with the molecular formula C7H5Cl2NO. It is a white crystalline solid that is often used as a reagent in organic synthesis. Its main use is in the preparation of various pharmaceuticals and agrochemicals. 2,6-Dichlorobenzaldoxime is also used as an intermediate in the production of dyes and other organic compounds. It is important to handle this chemical with care, as it is toxic if ingested or inhaled and can cause irritation to the skin and eyes. Overall, 2,6-Dichlorobenzaldoxime plays an essential role in the synthesis of various compounds and is an important chemical in the pharmaceutical and agrochemical industries.

InChI:InChI=1/C7H5Cl2NO/c8-6-2-1-3-7(9)5(6)4-10-11/h1-4,11H/b10-4-

Upstream product

• 50-30-6 2,6-dichlorobenzoic acid 
• 83-38-5 2,6-dichlorobenzaldehyde 

Downstream Products

• 1194-65-6 2,6-dichloro-benzonitrile 
• 1208328-50-0 N-acetoxy-2,6-dichloro-benzamide 
• 2593-24-0 2,6-dichloro-N-hydroxybenzamide 
• 958986-15-7 2-(3-(2,6-dichlorophenyl)-4,5-dihydroisoxazol-5-yl)-5-phenyl-1,3,4-oxadiazole 
• 1918-13-4 chlorthiamid 
• 1424395-05-0 C₂₈H₂₃Cl₄N₃O₅ 
• 1424394-90-0 C₁₁H₉Cl₂NO₃ 
• 1424394-80-8 C₁₂H₁₁Cl₂NO₃ 
• 873-32-5 2-Chlorobenzonitrile 
• 13180-88-6 2-[1-(2,6-Dichloro-phenyl)-meth-(Z)-ylideneaminooxy]-3,5-dinitro-benzoic acid methyl ester 

Relevant articles and documents

Design, synthesis and antimycobacterial activity of various 3-(4-(substitutedsulfonyl)piperazin-1-yl)benzo[ d[isoxazole derivatives

In this communication, we synthesized a series of twenty four novel 3-(4-(substitutedsulfonyl)piperazin-1-yl)benzo[d]isoxazole analogues, characterized using various spectroscopic techniques and evaluated for their in vitro anti-tubercular activity against Mycobacterium tuberculosis (MTB) H37Rv strain. The titled compounds exhibited Minimum inhibitory concentration (MIC) between 3.125 and >50 μg/mL. Among the tested compounds, 5c, 6a, 6j and 6p exhibited moderate activity (MIC Combining double low line 12.5 μg/mL), while 5a and 6i exhibited good activity (MIC Combining double low line 6.25 μg/mL) and 6b (MIC Combining double low line 3.125 μg/mL) exhibited very good anti-tubercular activity. In addition, the analogues 5a, 5c, 6a, 6b, 6i, 6j and 6p were subjected to toxicity studies against mouse macrophage (RAW 264.7) cell lines to analyse the selectivity profile of the newly synthesized compounds and selectivity index of the most active compound was found to be >130 indicating suitability of the compound for further drug development. Structure of 6b was further substantiated through single crystal XRD.

Palladium-Catalyzed (3+3) Annulation of Allenylethylene Carbonates with Nitrile Oxides

In this paper, we designed and synthesized a new type of cyclic carbonates, allenylethylene carbonates (AECs). With AECs as reactive precursors, we developed palladium-catalyzed (3+3) annulation of AECs with nitrile oxides. Various AECs worked well in this reaction under mild reaction conditions. A variety of 5,6-dihydro-1,4,2-dioxazine derivatives with allenyl quaternary stereocenters can be accessed in a facile manner in high yields (≤98%).

Discovery of a novel and orally active Farnesoid X receptor agonist for the protection of acetaminophen-induced hepatotoxicity

Acetaminophen (APAP) overdose is a leading cause of acute hepatic failure and liver transplantation, while the existing treatments are poorly effective. Therefore, it is necessary to develop effective therapeutic drugs for APAP-induced hepatotoxicity. Farnesoid X receptor (FXR) is a potential target for the treatment of liver disease, and the activation of FXR protects mice against APAP-induced hepatotoxicity. Compound 5, a glycine-conjugated derivative of FXR agonist 4, was designed to extend the chemical space of existing FXR agonists. Molecular modeling study indicated that compound 5 formed hydrogen bond network with key residues of FXR. Moreover, compound 5 (10?mg/kg) revealed better protective effects against APAP-induced hepatotoxicity than parent compound 4 (30?mg/kg). Further mechanical research indicated that compound 5 regulated the expressions of genes related to FXR and oxidative stress. These findings suggest that compound 5 is a promising FXR agonist suitable for further research, and it is the first time to verify that the glycine-conjugated derivative five exerted better protective effects than its parent compound.