25189-55-3

Basic information

• Product Name: POLY(N-ISOPROPYL ACRYLAMIDE)
• Synonyms: n-(1-methylethyl)-2-propenamidhomopolymer;poly(n-iso-propylacrylamide)(mw20000-25000);nipam polymer;2-Propenamid, N-(1-methylethyl)-, Homopolymer;2-Propenamide, N-(1-methylethyl)-, homopolymer n-(1-methylethyl)-2-propenamid homopolymer;N-(1-Methylethyl)-2-propenamide homopolymer;Poly(N-isopropylacrylamide),NIPAM polymer, PNIPAM, Polyacrylamide, polyNIPAM;PNIPAM
• CAS NO: 25189-55-3
• Molecular Formula: C6H11NO
• Molecular Weight: 113.15764
• Product Categories: Acrylamides;Acrylics;Biomaterials;Hydrogels and Crosslinked Polymers;Hydrophilic Polymers;Materials Science;Polymer Science;Polymers
• Mol File: 25189-55-3.mol
• Article Data: 0

Chemical Properties

• Melting Point: 96 °C(lit.)
• Boiling Point: 234.2 °C at 760 mmHg
• Flash Point: 126 °C
• Appearance: White to Off-White
• Density: 0.879 g/cm³
• Vapor Pressure: 0.0535mmHg at 25°C
• Refractive Index: 1.429
• Storage Temp.: 2-8°C
• CAS DataBase Reference: POLY(N-ISOPROPYL ACRYLAMIDE)(CAS DataBase Reference)
• NIST Chemistry Reference: POLY(N-ISOPROPYL ACRYLAMIDE)(25189-55-3)
• EPA Substance Registry System: POLY(N-ISOPROPYL ACRYLAMIDE)(25189-55-3)

Safety Data

• WGK Germany: 1
• Hazardous Substances Data: 25189-55-3(Hazardous Substances Data)

Usage

Description

Poly(N-isopropylacrylamide) (PNIPAM) is a temperature-responsive polymer derived from the polymerization of N-isopropylamide. It is known for its reversible, lower critical solution temperature (LCST) phase transition at around 32 °C, where it transitions from a soluble to an insoluble state. PNIPAM is also characterized by its narrow distribution of chain lengths, which contributes to better reproducibility. This polymer is widely used in biomedical research applications, including tissue engineering and controlled drug delivery, due to its similarity in temperature with the human body.

Uses

Used in Biomedical Research:
Poly(N-isopropyl acrylamide) is used as a temperature-responsive polymer for the development of thermosensitive coated micro/nano materials. Its phase transition at 32 °C makes it suitable for applications in biomedical research, particularly in the field of tissue engineering and controlled drug delivery.
Used in Drug Delivery Systems:
PNIPAM is used as a thermoresponsive polymeric drug delivery system. The carboxylic acid functional group present in the polymer allows for the conjugation of various biomolecules to the polymer chain, enhancing its potential in targeted drug delivery and improving therapeutic outcomes.
Used in Hydrogel Formation:
Poly(N-isopropyl acrylamide) is used as a hydrogel-forming material. Its aqueous polymer solution undergoes a phase transition from a soluble to an insoluble state when the temperature is raised to approximately 32 °C. This property makes PNIPAM hydrogels ideal for various applications, including tissue engineering and controlled release of bioactive molecules.
Used in Amphiphilic Block Copolymers:
PNIPAM is used as the hydrophilic block in the synthesis of thermoresponsive, amphiphilic block copolymers. These copolymers have potential applications in the development of novel materials with tunable properties for various industries, such as pharmaceuticals, biotechnology, and materials science.
Used in Coatings and Materials Science:
Poly(N-isopropyl acrylamide) is used as a component in the development of thermosensitive coatings and materials. Its temperature-responsive nature allows for the creation of materials with tunable properties, making it suitable for various applications in different industries, such as electronics, sensors, and environmental protection.

InChI:InChI=1/C6H11NO/c1-3-5-7-6(8)4-2/h4H,2-3,5H2,1H3,(H,7,8)