251908-92-6 Usage
Uses
AM 1172 is a potent and selective inhibitor of anandamide uptake and FAAH.
Biological Activity
Metabolically stable anandamide uptake inhibitor (IC 50 = 2.1 - 2.5 μ M) and fatty acid amide hydrolase (FAAH) inhibitor (K i = 3.18 μ M). Inhibits N -arachidonylethanolamine (AEA) accumulation (IC 50 = 24 μ M) and hydrolysis (K i = 3 μ M), and inhibits N -palmitoylethanolamine (PEA) hydrolysis (IC 50 = 36 μ M) in cerebellar granule neurons. Also acts as a non-selective cannabinoid receptor partial agonist (EC 50 values are 189 and 271 nM at CB 2 and CB 1 receptors respectively).
references
1. fegley d, kathuria s, mercier r, et al. anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor am1172. proceedings of the national academy of sciences of the united states of america. 2004;101(23):8756-8761.
Check Digit Verification of cas no
The CAS Registry Mumber 251908-92-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,5,1,9,0 and 8 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 251908-92:
(8*2)+(7*5)+(6*1)+(5*9)+(4*0)+(3*8)+(2*9)+(1*2)=146
146 % 10 = 6
So 251908-92-6 is a valid CAS Registry Number.
InChI:InChI=1/C27H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24-28-27(30)25-20-22-26(29)23-21-25/h6-7,9-10,12-13,15-16,20-23,29H,2-5,8,11,14,17-19,24H2,1H3,(H,28,30)/b7-6-,10-9-,13-12-,16-15-
