251924-83-1

Basic information

• Product Name: 1-tert-butyl 2-ethyl 5-oxopyrrolidine-1,2-dicarboxylate
• Synonyms: 1-tert-butyl 2-ethyl 5-oxopyrrolidine-1,2-dicarboxylate;N-Boc-DL-pyroglutamic acid ethyl ester
• CAS NO: 251924-83-1
• Molecular Formula: C12H19NO5
• Molecular Weight: 257.28296
• Mol File: 251924-83-1.mol
• Article Data: 44

Chemical Properties

• Boiling Point: 375.0±35.0 °C(Predicted)
• Appearance: /
• Density: 1.182±0.06 g/cm3(Predicted)
• PKA: -4.15±0.40(Predicted)
• CAS DataBase Reference: 1-tert-butyl 2-ethyl 5-oxopyrrolidine-1,2-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-tert-butyl 2-ethyl 5-oxopyrrolidine-1,2-dicarboxylate(251924-83-1)
• EPA Substance Registry System: 1-tert-butyl 2-ethyl 5-oxopyrrolidine-1,2-dicarboxylate(251924-83-1)

Safety Data

• Hazardous Substances Data: 251924-83-1(Hazardous Substances Data)

Usage

General Description

1-tert-butyl 2-ethyl 5-oxopyrrolidine-1,2-dicarboxylate, also known as Tert-butyl ethyl pyrrolidine-2,5-dicarboxylate, is a chemical compound with the molecular formula C14H23NO6. It is a pyrrolidine derivative, which is commonly used in organic synthesis and medicinal chemistry. 1-tert-butyl 2-ethyl 5-oxopyrrolidine-1,2-dicarboxylate is often used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It possesses potential therapeutic properties and has been studied for its potential application in the treatment of various diseases and disorders. Additionally, it is known for its role as an intermediate in the production of various chemical compounds and has been used in the development of new drug candidates.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 68766-96-1 ethyl (R)-2-pyrrolidone-5-carboxylate 
• 7149-65-7 ethyl (S)-pyroglutamate 
• 66183-71-9 ethyl 2-oxopyrrolidine-5-carboxylate 
• 149-87-1 Pyroglutamic acid 
• 86938-17-2 2-(S)-tert-butoxycarbonylaminopentanedioic acid 1-ethyl ester 
• 52454-78-1 L-glutamic acid α-ethyl ester 
• 1118-89-4 diethyl-L-glutamate hydrochloride 
• 24608-52-4 tert-butyl chloroformate 
• 64-17-5 ethanol 
• 98-79-3 L-Pyroglutamic acid 
• 122-51-0 orthoformic acid triethyl ester 
• 4042-36-8 D-pyrrolidone-5-carboxylic acid 
• 1538-75-6 2,2-dimethylpropanoic anhydride 

Downstream Products

• 144978-17-6 (S)-2-tert-Butoxycarbonylamino-6-(diethoxy-phosphoryl)-5-oxo-hexanoic acid ethyl ester 
• 144978-32-5 (Z)-(R)-2-tert-Butoxycarbonylamino-7-hydroxy-5-oxo-7-phenyl-hept-6-enoic acid ethyl ester 
• 144978-13-2 (Z)-(S)-2-tert-Butoxycarbonylamino-7-hydroxy-5-oxo-7-phenyl-hept-6-enoic acid ethyl ester 
• 153783-18-7 Ethyl (S)-2-(tert-butoxycarbonylamino)-5-phenyl-5-oxopentanoate 
• 1056469-57-8 ethyl (2R)-2-{[(tert-butoxy)carbonyl]amino}-5-oxo-5-phenylpentanoate 
• 153783-21-2 Ethyl (S)-2-(tert-butoxycarbonylamino)-5-oxo-5-(p-tolyl)pentanoate 
• 881683-80-3 ethyl (2S)-N-Boc-2-amino-5-oxo-non-8-enoate 
• 1448309-79-2 (2S,5S)-N-((R)-1-(2-chlorophenyl)-2-(4,4-difluorocyclohexylamino)-2-oxoethyl)-N-(3-fluorophenyl)-5-methyl-1-(pyrimidin-2-yl)pyrrolidine-2-carboxamide 
• 1448309-80-5 (2S,5S)-N-((S)-1-(2-chlorophenyl)-2-(4,4-difluorocyclohexylamino)-2-oxo ethyl)-N-(3-fluorophenyl)-5-methyl-1-(pyrimidin-2-yl)pyrrolidine-2-carboxamide 
• 676560-85-3 (2S,5S)-ethyl 5-methylpyrrolidine-2-carboxylate 2,2,2-trifluoro acetate salt 
• 158392-80-4 1-tert-butyl 2-ethyl (2S)4,4-dimethyl-5-oxopyrrolidine-1,2-dicarboxylate 
• 144978-14-3 (Z)-(S)-2-tert-Butoxycarbonylamino-7-hydroxy-7-(3-methoxy-phenyl)-5-oxo-hept-6-enoic acid ethyl ester 
• 144978-33-6 (Z)-(R)-2-tert-Butoxycarbonylamino-7-hydroxy-7-(3-methoxy-phenyl)-5-oxo-hept-6-enoic acid ethyl ester 
• 153080-81-0 (2S,4R)-1-tert-butyl 4-allyl-2-ethoxycarbonyl-5-oxopyrrolidine-1-carboxylate 

Relevant articles and documents

INHIBITORS OF NOROVIRUS AND CORONAVIRUS REPLICATION

Compounds of Formula (I) and methods of inhibiting the replication of viruses in a biological sample or patient, of reducing the amount of viruses in a biological sample or patient, and of treating a virus infection in a patient, comprising administering to said biological sample or patient an effective amount of a compound represented by Formula (I), a compound of Table A or B or a pharmaceutically acceptable salt thereof.

Green preparation method of N-substituted-L-pyroglutamate

The invention provides a green preparation method of N-substituted-L-pyroglutamate. The method comprises the steps as follows: L-glutamic acid diester hydrochloride (III) is prepared from L-glutamic acid (II) as a starting material in the presence of an acidic reagent by an esterification reaction; then, L-glutamic acid diester hydrochloride (III) is subjected to N-substituted protective reactionwith an N-substituent protective reagent with a one-pot method in the presence of a base and a solvent, an N-substituted protective group is introduced, heating is performed for dealcoholization cyclization in molecules, and N-substituted-L-pyroglutamate as shown in the formula (I) is obtained. The method has the advantages of cheap and easily available raw materials, classic reaction types, shortprocess route, simple and convenient operation, small waste water amount, green and environment-friendly production process, high reaction yield and low product cost. 5R-benzyloxyaminopiperidine-2S-carboxylate, 5R-benzyloxyaminopiperidine-2S-formate ethanedioate and avibactam can be prepared from N-substituted-L-pyroglutamate as shown in the formula (I).

PROCESS FOR PREPARING DIPEPTIDYL PEPTIDASE IV INHIBITORS AND INTERMEDIATES THEREFOR

A process for preparing an amine of the structure which comprises a. treating an aqueous solution of a keto acid of the structure with ammonium formate, nicotinamide adenine dinucleotide, dithiothreitol and partially purified phenylalanine dehydrogenase and/or formate dehydrogenase enzyme (PDH/FDH); and b. adjusting pH of the reaction mixture with sodium hydroxide to form the desired amine which is substantially free of undesirable excess ammonium ions.