25209-42-1 Usage
General Description
3-Chloro-2,2-diphenylpropanoic acid is a chemical compound with the molecular formula C15H13ClO2. It is a chlorinated derivative of 2,2-diphenylpropanoic acid and is part of a group of chemicals known as diphenylalkanoic acids. 3-chloro-2,2-diphenylpropanoic acid is commonly used as a pharmaceutical intermediate in the synthesis of various drugs and is also used as a building block in organic synthesis. It is a white solid at room temperature and is sparingly soluble in water. The presence of the chloro group gives it unique chemical properties and has implications for its reactivity and environmental fate.
Check Digit Verification of cas no
The CAS Registry Mumber 25209-42-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,5,2,0 and 9 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 25209-42:
(7*2)+(6*5)+(5*2)+(4*0)+(3*9)+(2*4)+(1*2)=91
91 % 10 = 1
So 25209-42-1 is a valid CAS Registry Number.
25209-42-1Relevant articles and documents
Cu-Catalyzed Alkynylation of Unactivated C(sp3)-X Bonds with Terminal Alkynes through Directing Strategy
Luo, Fei-Xian,Xu, Xing,Wang, Ding,Cao, Zhi-Chao,Zhang, Yun-Fei,Shi, Zhang-Jie
supporting information, p. 2040 - 2043 (2016/06/01)
In this letter, we report an efficient and concise protocol for Cu-catalyzed cross-coupling of unactivated alkyl halides/peusudohalides with terminal alkynes to afford internal alkynes with the assistance of various amides as directing groups. Different alkyl halides/pseudohalides exhibited excellent reactivities, and the inactivated alkyl chlorides and sulfonates showed better reactivity than bromides/iodides. This is the first successful example to apply alkyl chlorides and sulfonates directly in cross-coupling with terminal alkynes in the absence of any additives. A Cu catalyst was found to be more effective than other transition metal catalysts. This reaction also exhibited a broad substrate scope with respect to terminal alkynes.
