252204-14-1

Basic information

• Product Name: [N-(tert-butyloxycarbonyl)-N-(3-chloro-2-propen-1-yl)amino]-2,4-dimethoxy-6-iodo-5-(methoxymethoxy)-3-methylbenzene
• Synonyms: [N-(tert-butyloxycarbonyl)-N-(3-chloro-2-propen-1-yl)amino]-2,4-dimethoxy-6-iodo-5-(methoxymethoxy)-3-methylbenzene
• CAS NO: 252204-14-1
• Molecular Weight: 527.784
• Mol File: 252204-14-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: [N-(tert-butyloxycarbonyl)-N-(3-chloro-2-propen-1-yl)amino]-2,4-dimethoxy-6-iodo-5-(methoxymethoxy)-3-methylbenzene(CAS DataBase Reference)
• NIST Chemistry Reference: [N-(tert-butyloxycarbonyl)-N-(3-chloro-2-propen-1-yl)amino]-2,4-dimethoxy-6-iodo-5-(methoxymethoxy)-3-methylbenzene(252204-14-1)
• EPA Substance Registry System: [N-(tert-butyloxycarbonyl)-N-(3-chloro-2-propen-1-yl)amino]-2,4-dimethoxy-6-iodo-5-(methoxymethoxy)-3-methylbenzene(252204-14-1)

Safety Data

• Hazardous Substances Data: 252204-14-1(Hazardous Substances Data)

Upstream product

• 227084-75-5 [N-(tert-butyloxycarbonyl)amino]-2,4-dimethoxy-5-(methoxymethoxy)-3-methylbenzene 
• 227084-73-3 2,4-dimethoxy-3-methyl-5-nitro-1-(methoxymethoxy)benzene 
• 19676-67-6 2,4-dimethoxy-3-methylphenol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 227084-62-0 [N-(tert-butyloxycarbonyl)amino]-2,4-dimethoxy-6-iodo-5-(methoxymethoxy)-3-methylbenzene 
• 10061-02-6 (E)-1,3-dichloro-prop-1-ene 
• 542-75-6 E/Z-1,3-Dichloropropene 
• 227084-74-4 5-amino-2,4-dimethoxy-3-methyl-1-(methoxymethoxy)benzene 
• 126809-69-6 2,4-dimethoxy-3-methyl-1-(methoxymethoxy)benzene 

Relevant articles and documents

Synthesis of CC-1065 and duocarmycin analogs via intramolecular aryl radical cyclization of a tethered vinyl chloride

The 5-exo-trig radical cyclization of an aryl halide onto a tethered vinyl chloride produces the 3-chloromethyl dihydroindole precursors for CC- 1065 and duocarmycin analogs with chlorine installed as a suitable leaving group for subsequent cyclopropane spirocyclization. The generality of this approach was examined in the context of six CC-1065 and duocarmycin analogs previously synthesized in this laboratory.