25243-95-2 Usage
Description
(3S)-3-octanoyloxy-4-trimethylazaniumylbutanoate, also known as Octanoyl-L-carnitine, is a medium-chain endogenous ester of L-carnitine, obtained via acylcarnitine family transferase. It is the L-enantiomer of an O-octanoylcarnitine.
Uses
Used in Analytical Standards:
(3S)-3-octanoyloxy-4-trimethylazaniumylbutanoate is used as an analytical standard for the separation and identification of underivatized octanoyl-L-carnitine in human plasma samples using high-performance liquid chromatography coupled to tandem mass spectrometry (HPLC-MS/MS).
Used in Quantification of Analytes in Biological Samples:
(3S)-3-octanoyloxy-4-trimethylazaniumylbutanoate is used as a quantification standard for the analyte in biological samples of patients treated with continuous ambulatory peritoneal dialysis (CAPD) or automated peritoneal dialysis (APD) using high-performance liquid chromatography/tandem quadrupole mass spectrometry (HPLC-TQMS).
Used in Investigation of Feasibility of Adding L-carnitine to PD Solution:
(3S)-3-octanoyloxy-4-trimethylazaniumylbutanoate is used as a test material for investigating the feasibility of adding L-carnitine to the peritoneal dialysis (PD) solution in APD-treated end-stage renal disease patients.
Used in Investigation of Oxidation Rate by Mitochondria:
(3S)-3-octanoyloxy-4-trimethylazaniumylbutanoate is used as a test material for investigating its rate of oxidation by mitochondria, isolated from the livers of fed, starved, and glucagon treated virgin and lactating rats.
Biochem/physiol Actions
L-Octanoylcarnitine is the physiologically active form of octanoylcarnitine and is detected in medium-chain acyl-CoA dehydrogenase (MCAD) deficiency. MCAD is characterized by intolerance to prolonged fasting, recurrent episodes of hypoglycemic coma with medium-chain dicarboxylic aciduria, impaired ketogenesis, and low plasma and tissue carnitine levels.
Check Digit Verification of cas no
The CAS Registry Mumber 25243-95-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,5,2,4 and 3 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 25243-95:
(7*2)+(6*5)+(5*2)+(4*4)+(3*3)+(2*9)+(1*5)=102
102 % 10 = 2
So 25243-95-2 is a valid CAS Registry Number.
InChI:InChI=1/C15H29NO4/c1-5-6-7-8-9-10-15(19)20-13(11-14(17)18)12-16(2,3)4/h13H,5-12H2,1-4H3/t13-/m0/s1
25243-95-2Relevant articles and documents
Differentiation of Isomeric Acylcarnitines Using Tandem Mass Spectrometry
Gaskell, Simon, J.,Guenat, Christian,Millington, David S.,Maltby, David A.,Roe, Charles R.
, p. 2801 - 2805 (2007/10/02)
Tandem mass spectrometry, using a four-sector instrument, has been used to distinguish isomeric acylcarnitines.Collisional activation of MH+ ions (or of acylcarnitine methyl ester cations) induces fragmentations of the acyl moieties, yielding daughter ions with relative abundances characteristic of individual isomers.Direct analyses of crude urine samples from children with metabolic disorders enable unequivocal identification of individual acylcarnitines, thus contributing to the characterization of the disorder.
