2525-99-7

Basic information

• Product Name: 2-(4-Brom-butoxy)-β-phenyl-propiophenon
• CAS NO: 2525-99-7
• Molecular Weight: 361.279
• Mol File: 2525-99-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4-Brom-butoxy)-β-phenyl-propiophenon(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Brom-butoxy)-β-phenyl-propiophenon(2525-99-7)
• EPA Substance Registry System: 2-(4-Brom-butoxy)-β-phenyl-propiophenon(2525-99-7)

Safety Data

• Hazardous Substances Data: 2525-99-7(Hazardous Substances Data)

Upstream product

• 110-52-1 1,4-dibromo-butane 
• 3516-95-8 2'-hydroxy-3-phenylpropiophenone 
• 64-17-5 ethanol 

Downstream Products

• 2631-02-9 GPV 195 

Relevant articles and documents

Studies on propafenone-type modulators of multidrug resistance VI. Synthesis and pharmacological activity of compounds with varied spacer length between the central aromatic ring and the nitrogen atom

A series of propafenone-type modulators of multidrug resistance (MDR) with varied spacer length between the central aromatic ring and the positively chargeable nitrogen atom was synthesized and tested for their ability to block P-glycoprotein-mediated transport of daunomycin out of tumor cells. Synthesis was achieved by O-alkylation of o-hydroxy-3- phenylpropiophenone with dibromoalkanes and subsequent nucleophilic substitution of the bromine with piperidine. All compounds showed high MDR- modulating activity with EC50 values from 1.450.15 μM. Generally, activity increased with increasing number of methylene groups, whereby it reaches a plateau for compounds with more than five methylene groups between the ether oxygen and the nitrogen atom.