25292-25-5Relevant articles and documents
Strategy to Prepare 3-Bromo- and 3-Chloropyrazoles
Fox, Richard J.,Schmidt, Michael A.,Eastgate, Martin D.
, p. 2830 - 2839 (2018/03/09)
A general strategy to prepare substituted 3-bromo- and 3-chloropyrazoles is described. The three-step method involves condensation of crotonates or β-chloro carboxylic acids with hydrazines, followed by halogenation and oxidation. Several condensation and oxidation protocols were developed to enable preparation of a wide variety of 3-halopyrazoles with good to excellent yields and regiocontrol.
Enantioselective conjugate addition of hydrazines to α,β- unsaturated imides. Synthesis of chiral pyrazolidinones
Sibi, Mukund P.,Soeta, Takahiro
, p. 4522 - 4523 (2007/10/03)
This manuscript describes a highly enantioselective conjugate hydrazine addition to α,β-unsaturated imides. The achiral template used has a significant impact on product enantioselectivity. Reactions at lower temperatures provide a protocol to add substit
