25303-66-6

Basic information

• Product Name: Ethanone, 1-(3-methylenecyclobutyl)- (9CI)
• Synonyms: Ethanone, 1-(3-methylenecyclobutyl)- (9CI);1-(3-METHYLENECYCLOBUTYL)ETHANONE
• CAS NO: 25303-66-6
• Molecular Formula: C₇H₁₀O
• Molecular Weight: 110.1537
• Product Categories: ACETYLGROUP
• Mol File: 25303-66-6.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethanone, 1-(3-methylenecyclobutyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(3-methylenecyclobutyl)- (9CI)(25303-66-6)
• EPA Substance Registry System: Ethanone, 1-(3-methylenecyclobutyl)- (9CI)(25303-66-6)

Safety Data

• Hazardous Substances Data: 25303-66-6(Hazardous Substances Data)

Upstream product

• 917-64-6 methyl magnesium iodide 
• 15760-35-7 3-methylenecyclobutanecarbonitrile 
• 917-54-4 methyllithium 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 1418274-55-1 5-((1s,3s)-3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxycyclobutyl)-1-isopropyl-1H-pyrazole-3-carboxylic acid 
• 1418274-56-2 5-((1r,3r)-3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxycyclobutyl)-1-isopropyl-1H-pyrazole-3-carboxylate 
• 1418274-69-7 ethyl 5-((1s,3s)-3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxycyclobutyl)-1-isopropyl-1H-pyrazole-3-carboxylate 
• 107693-40-3 1-(3-Hydroxy-3-methyl-cyclobutyl)-ethanone 
• 107693-40-3 1-(3-Hydroxy-3-methyl-cyclobutyl)-ethanone 
• 42809-12-1 1-(3-Methyl-cyclobutyl)-ethanone 
• 42809-13-2 1-acetyl-3-methylcyclobutane 

Relevant articles and documents

Synthesis of 3-(5H-pyrazolyl)cyclobutanone derivatives

A 3-(5H-pyrazolyl)cyclobutanone derivative was synthesized via two different optimized routes. In the first route, the substitutional pyrazole olefins was prepared as a precursor, the target molecule was synthesized via [2 + 2]-cycloaddition by using pyrazols olefins and ketene in total yield of 3 %. In the second route, the four-member ring cyclobutanone fragment was made first, then the pyrazole ring was obtained through cyclization, offering the target molecule with a yield of 8.6 %.

NOVEL FXR (NR1H4) BINDING AND ACTIVITY MODULATING COMPOUNDS

The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.