253122-83-7

Basic information

• Product Name: C₁₀H₅F₆NO₂
• Synonyms: C₁₀H₅F₆NO₂
• CAS NO: 253122-83-7
• Molecular Weight: 285.146
• Mol File: 253122-83-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₀H₅F₆NO₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₀H₅F₆NO₂(253122-83-7)
• EPA Substance Registry System: C₁₀H₅F₆NO₂(253122-83-7)

Safety Data

• Hazardous Substances Data: 253122-83-7(Hazardous Substances Data)

Upstream product

• 75-52-5 nitromethane 
• 85068-29-7 3,5-bis-trifluoromethylbenzylamine 

Downstream Products

• 1268464-52-3 (2R,3S,4R)-4-(3,5-bis(trifluoromethyl)phenyl)-2-phenyl-3-(phenylsulfonyl)-1-(trimethylsilyloxy)pyrrolidine-2-carbonitrile 
• 1268464-43-2 (3S,4R)-3-[3,5-bis(trifluoromethyl)phenyl]-5-phenyl-4-(phenylsulfonyl)-3,4-dihydro-2H-pyrroline-1-oxide 
• 1268464-42-1 (3R,4S)-3-[3,5-bis(trifluoromethyl)phenyl]-5-phenyl-4-(phenylsulfonyl)-3,4-dihydro-2H-pyrroline-1-oxide 
• 1268464-28-3 (3S)-3-[3,5-bis(trifluoromethyl)phenyl]-4-nitro-1-phenyl-2-(phenylsulfonyl)butan-1-one 
• 1268464-27-2 (3R)-3-[3,5-bis(trifluoromethyl)phenyl]-4-nitro-1-phenyl-2-(phenylsulfonyl)butan-1-one 

Relevant articles and documents

Substrate promiscuity of ortho-naphthoquinone catalyst: Catalytic aerobic amine oxidation protocols to deaminative cross-coupling and n-nitrosation

ortho-Naphthoquinone-based organocatalysts have been identified as versatile aerobic oxidation catalysts. Primary amines were readily cross-coupled with primary nitroalkanes via deaminative pathway to give nitroalkene derivatives in good to excellent yields. Secondary and tertiary amines were inert to ortho-naphthoquinone catalysts; however, secondary nitroalkanes were readily converted by ortho-naphthoquinone catalysts to the corresponding nitrite species that in situ oxidized the amines to the corresponding N-nitroso compounds. Without using harsh oxidants in a stoichiometric amount, the present catalytic aerobic oxidation protocol utilizes the substrate promiscuity feature to provide a facile access to amine oxidation products under mild reaction conditions.