25328-81-8

Basic information

• Product Name: 2-Propenoic acid, 2-(methoxymethyl)-, methyl ester
• Synonyms: methyl 2-methoxymethylacrylate;2-(Methoxymethyl)acrylsaeure-methylester;2-Propenoic acid,2-(methoxymethyl)-,methyl ester
• CAS NO: 25328-81-8
• Molecular Formula: C6H10O3
• Molecular Weight: 130.144
• Mol File: 25328-81-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 100-125 °C
• Density: 0.983±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-Propenoic acid, 2-(methoxymethyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 2-(methoxymethyl)-, methyl ester(25328-81-8)
• EPA Substance Registry System: 2-Propenoic acid, 2-(methoxymethyl)-, methyl ester(25328-81-8)

Safety Data

• Hazardous Substances Data: 25328-81-8(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 15484-46-5 methyl 2-hydroxymethylacrylate 
• 107-19-7 propargyl alcohol 
• 201230-82-2 carbon monoxide 
• 4224-69-5 methyl 2-(bromomethyl)propenoate 
• 124-41-4 sodium methylate 
• 463-49-0 1,2-propanediene 
• 72707-68-7 (2-(methoxycarbonyl)allyl)triphenylphosphonium bromide 

Downstream Products

• 942189-76-6 methyl 1-benzyl-3-methoxymethyl-pyrrolidine-3-carboxylate 
• 1415690-15-1 C₁₇H₂₄O₆ 
• 1026711-32-9 3-(3-cyano-phenyl)-5-methoxymethyl-4,5-dihydro-isoxazole-5-carboxylic acid [5-(2-tert-butylsulfamoyl-phenyl)-pyrimidin-2-yl]-amide 
• 231300-26-8 5-isoxazolecarboxamide, 3-(3-cyanophenyl)-N-<5-<2'-(tert-butylaminosulfonyl)phenyl>-2-pyridinyl>-4,5-dihydro-5-(3-methoxymethyl)- 

Relevant articles and documents

New insights into the alkoxycarbonylation of propargyl alcohol

The challenging carbonylation of propargyl alcohol is effectively catalyzed by Pd(OAc)2 in combination with diphenyl-(6-methyl-pyridin-2-yl)phosphine and methanesulfonic acid. In dichloroethane at 20–50 °C, the reaction affords with almost complete regioselectivity alkyl 2-(hydroxymethyl)acrylates. Turnover frequency numbers (TOF) of up to 450 h?1 can be achieved working at 50 °C, while a maximum turnover number (TON) of about 730 is obtained at 30 °C. The catalyst longevity is limited because the carbonylation product reacts with the phosphorus atom of the ligand to give a quaternary phosphonium salt. This reaction leads to deactivation of the catalyst and eventually to palladium black formation.

PYRROLIDINE DERIVATIVES AS ERK INHIBITORS

Disclosed are the ERK inhibitors of Formula (1.0): and the pharmaceutically acceptable salts and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of Formula (1.0).

Oxidative methoxycarbonylation of propyne and allene with carbon monoxide and methanol in the presence of copper-palladium catalyst

A direct oxidative methoxycarbonylation of propyne with carbon monoxide in methanol medium in the presence of copper-palladium catalytic system results in methyl 2-butynoate in 18-31% yield. Depending on reaction conditions allene provides either a mixture of methyl 2-(chloromethyl)acrylate and methyl 2-(methoxymethyl)acrylate (～3-4:1) in overall yield 16-23%, or methyl 2-(methoxymethyl)acrylate in 19% yield.