253344-33-1

Basic information

• Product Name: (S)-2,4-Bis-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-butyric acid
• CAS NO: 253344-33-1
• Molecular Weight: 612.723
• Mol File: 253344-33-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2,4-Bis-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-butyric acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2,4-Bis-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-butyric acid(253344-33-1)
• EPA Substance Registry System: (S)-2,4-Bis-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-butyric acid(253344-33-1)

Safety Data

• Hazardous Substances Data: 253344-33-1(Hazardous Substances Data)

Upstream product

• 1758-80-1 L-2,4-diaminobutyrate 
• 3674-06-4 Boc-Phe-ONSu 

Downstream Products

• 253344-35-3 {1-[3-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-1-hydroxymethyl-propylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester 
• 1027841-46-8 (S)-2-Amino-N-[(S)-3-((S)-2-amino-3-phenyl-propionylamino)-1-hydroxymethyl-propyl]-3-phenyl-propionamide 

Relevant articles and documents

Symmetry-based inhibitors of HIV-1 protease. Design, synthesis and preliminary structure-activity studies of acylated 2,3-diamino-1- hydroxypropanes and 2,4 diamino-1-hydroxybutanes

Two series of peptidomimetics containing a novel C2 pseudosymmetrical hydroxyalkyldiamino core structure were prepared from amino acid starting materials and tested for inhibitory activity against the HIV-1 protease (HIV- 1 Pt) and the virus in cell culture. In the 2,3-diamino-1-hydroxypropane series, compound 6a, containing P1/P1(I) benzyl and P2/P2(I) Fmoc substituents, displayed modest HIV-1 Pr inhibition (IC50 = 430 nM). The corresponding 2,4-diamino-1-hydroxybutane derivative (6b) was the best inhibitor of the series (IC50 = 160 nM). Interestingly, 6a and 6b showed satisfactory inhibition of HIV replication in cell culture. (ED50 = 340 and 110 nM, respectively), a result which suggests good cell membrane penetration by this class of compounds.