253429-19-5

Basic information

• Product Name: 7-Bromo-5-fluorobenzo[b]furan
• Synonyms: 7-Bromo-5-fluorobenzo[b]furan;7-Bromo-5-fluoro-1-benzofuran, 90%;7-bromo-5-fluorobenzofuran;5-Fluoro-7-bromobenzofuran
• CAS NO: 253429-19-5
• Molecular Formula: C₈H₄BrFO
• Molecular Weight: 215.03
• Mol File: 253429-19-5.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 233.37 °C at 760 mmHg
• Flash Point: 94.939 °C
• Appearance: /
• Density: 1.697 g/cm³
• Vapor Pressure: 0.085mmHg at 25°C
• Refractive Index: 1.612
• CAS DataBase Reference: 7-Bromo-5-fluorobenzo[b]furan(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Bromo-5-fluorobenzo[b]furan(253429-19-5)
• EPA Substance Registry System: 7-Bromo-5-fluorobenzo[b]furan(253429-19-5)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 253429-19-5(Hazardous Substances Data)

Usage

General Description

7-Bromo-5-fluorobenzo[b]furan is a chemical compound with the molecular formula C8H4BrFO. It is a derivative of benzo[b]furan, which is a heterocyclic compound containing a benzene ring fused to a furan ring. The presence of a bromine atom at the 7th position and a fluorine atom at the 5th position in the benzo[b]furan structure gives this compound unique chemical and physical properties. This chemical is used in the field of medicinal and pharmaceutical chemistry and may have potential applications in drug discovery and development. It is important to handle this compound with care due to its potential health hazards, particularly in terms of respiratory and skin irritation.

InChI:InChI=1/C8H4BrFO/c9-7-4-6(10)3-5-1-2-11-8(5)7/h1-4H

Upstream product

• 166281-37-4 2-bromo-4,5-difluorophenol 
• 695-96-5 2-bromo-4-chlorophenol 
• 496-69-5 2-bromo-4-fluoro-phenol 
• 7252-83-7 1-bromo-2,2-dimethoxyethane 
• 2105-94-4 4-bromo-2-fluorophenol 
• 253429-18-4 2-(2-bromo-4-fluorophenol) acetaldehyde diethyl acetal 
• 286836-10-0 2-(2-bromo-4,5-difluorophenoxy)-acetaldehyde diethyl acetal 
• 286836-08-6 2-(2-bromo-4-chlorophenoxy)-acetaldehyde diethyl acetal 

Downstream Products

• 325486-67-7 1-benzyl-3,3-dimethyl-4-(5-fluorobenzofuran-7-yl)-1,2,3,6-tetrahydropyridine 
• 325486-58-6 1-benzyl-3-methyl-4-(5-fluorobenzofur-7-yl)-1,2,5,6-tetrahydropyridine 
• 325486-57-5 1-benzyl-3-methyl-4-(5-fluorobenzofuran-7-yl)-1,2,3,6-tetrahydropyridine 
• 325486-63-3 1-benzyl-3-methyl-4-(5-fluorobenzofuran-7-yl)piperidine 
• 246029-02-7 5-fluorobenzofuran-7-ol 
• 325486-56-4 1-benzyl-3-methyl-4-hydroxy-4-(5-fluorobenzofuran-7-yl)-piperidine 
• 325486-66-6 1-benzyl-3,3-dimethyl-4-hydroxy-4-(5-fluorobenzofuran-7-yl)-piperidine 

Relevant articles and documents

Biocatalytic Strategy for Highly Diastereo- and Enantioselective Synthesis of 2,3-Dihydrobenzofuran-Based Tricyclic Scaffolds

2,3-Dihydrobenzofurans are key pharmacophores in many natural and synthetic bioactive molecules. A biocatalytic strategy is reported here for the highly diastereo- and enantioselective construction of stereochemically rich 2,3-dihydrobenzofurans in high enantiopurity (>99.9% de and ee), high yields, and on a preparative scale via benzofuran cyclopropanation with engineered myoglobins. Computational and structure-reactivity studies provide insights into the mechanism of this reaction, enabling the elaboration of a stereochemical model that can rationalize the high stereoselectivity of the biocatalyst. This information was leveraged to implement a highly stereoselective route to a drug molecule and a tricyclic scaffold featuring five stereogenic centers via a single-enzyme transformation. This work expands the biocatalytic toolbox for asymmetric C–C bond transformations and should prove useful for further development of metalloprotein catalysts for abiotic carbene transfer reactions.

NOVEL TRICYCLIC CALCIUM SENSING RECEPTOR ANTAGONISTS FOR THE TREATMENT OF OSTEOPOROSIS

Novel tricyclic compounds of the formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing osteoporosis and similar conditions. The compounds are effective as calcium sensing receptor antagonists. Pharmaceutical compositions and methods of treatment are also included.

Aminoalkylbenzofurans as serotonin (5-HT(2c)) agonists

The present invention provides serotonergic aminoalkylbenzofurans of Formula (I): where R, R1, R2, R3, R4, R4′, R5, R5′, and R12 are as described in the specification.