253453-91-7 Usage
Description
2-Chloro-1-methyl-1H-imidazole is an organic compound with the molecular formula C4H5N2Cl. It is a heterocyclic compound featuring a five-membered imidazole ring with a chlorine atom at the 2nd position and a methyl group at the 1st position. 2-Chloro-1-methyl-1H-imidazole is known for its versatile chemical properties and potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
2-Chloro-1-methyl-1H-imidazole is used as a pharmaceutical intermediate for the synthesis of various drugs and drug candidates. Its unique chemical structure allows it to be a key component in the development of new medications, particularly those targeting specific biological pathways or receptors.
Used in Chemical Catalysts:
In the field of catalysis, 2-Chloro-1-methyl-1H-imidazole serves as a ligand for transition metal catalysts. Its ability to form stable complexes with metal ions makes it a valuable component in the design and synthesis of catalysts for various chemical reactions, enhancing their efficiency and selectivity.
Used in Molecular Functional Materials:
2-Chloro-1-methyl-1H-imidazole is also utilized in the development of molecular functional materials. Its structural diversity and potential for modification make it a promising candidate for applications in areas such as sensors, optoelectronics, and molecular devices.
Check Digit Verification of cas no
The CAS Registry Mumber 253453-91-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,5,3,4,5 and 3 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 253453-91:
(8*2)+(7*5)+(6*3)+(5*4)+(4*5)+(3*3)+(2*9)+(1*1)=137
137 % 10 = 7
So 253453-91-7 is a valid CAS Registry Number.
InChI:InChI=1/C4H5ClN2/c1-7-3-2-6-4(7)5/h2-3H,1H3
253453-91-7Relevant articles and documents
Highly regioselective C-5 alkynylation of imidazoles by one-pot sequential bromination and Sonogashira cross coupling
Bellina, Fabio,Lessi, Marco,Marianetti, Giulia,Panattoni, Alessandro
supporting information, p. 3855 - 3857 (2015/06/08)
A variety of 2-substituted 5-alkynyl-1H-imidazoles were easily prepared by a one-pot sequential procedure involving a highly regioselective electrophilic C-5 bromination of 1,2-dimethyl-1H-imidazole, 2-chloro-1-methyl-1H-imidazole, and 2-aryl-1-methyl-1H-imidazoles, followed by an efficient palladium/copper co-catalyzed Sonogashira-type alkynylation.
Lewis basicity modulation of N-heterocycles: A key for successful cross-metathesis
Lafaye, Kevin,Nicolas, Lionel,Gurinot, Amandine,Reymond, Sbastien,Cossy, Janine
supporting information, p. 4972 - 4975 (2015/01/08)
Cross-metathesis involving N-heteroaromatic olefinic derivatives is disclosed. The introduction of an appropriate substituent on the heteroaromatic ring decreases the Lewis basicity of the nitrogen atom, thus preventing the deactivation of the ruthenium-centered catalyst. The reaction is quite general in terms of both N-heterocycles and olefinic partners.
A scalable synthesis of a histamine H3 receptor antagonist
Mani, Neelakandha S.,Jablonowski, Jill A.,Jones, Todd K.
, p. 8115 - 8117 (2007/10/03)
Starting from 1-methylimidazole, a concise, scalable, three-step synthesis of the title compound is described. The required 2-chloroimidazole was prepared in very good yield by halogen-metal exchange between the 2-lithio derivative and hexachloroethane.
