25361-54-0

Basic information

• Product Name: (2-amino-2-oxoethyl)(triphenyl)phosphonium chloride
• CAS NO: 25361-54-0
• Molecular Formula: C₂₀H₁₉NOP*Cl
• Molecular Weight: 355.7977
• Mol File: 25361-54-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (2-amino-2-oxoethyl)(triphenyl)phosphonium chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (2-amino-2-oxoethyl)(triphenyl)phosphonium chloride(25361-54-0)
• EPA Substance Registry System: (2-amino-2-oxoethyl)(triphenyl)phosphonium chloride(25361-54-0)

Safety Data

• Hazardous Substances Data: 25361-54-0(Hazardous Substances Data)

Usage

Description

(2-amino-2-oxoethyl)(triphenyl)phosphonium chloride is a phosphonium salt characterized by a cation with a phosphonium group attached to a 2-amino-2-oxoethyl group and three phenyl groups. (2-amino-2-oxoethyl)(triphenyl)phosphonium chloride is known for its versatility and value in chemical reactions and biological research due to its unique structure.

Uses

Used in Organic Synthesis:
(2-amino-2-oxoethyl)(triphenyl)phosphonium chloride is used as a reactant in organic synthesis for its ability to facilitate various chemical reactions, contributing to the formation of desired products.
Used as a Phase-Transfer Catalyst:
In the chemical industry, (2-amino-2-oxoethyl)(triphenyl)phosphonium chloride is utilized as a phase-transfer catalyst, enabling the transfer of the 2-amino-2-oxoethyl group between different phases, which is crucial for numerous chemical processes.
Used in Antimicrobial and Anti-Fungal Applications:
(2-amino-2-oxoethyl)(triphenyl)phosphonium chloride has been studied for its potential antimicrobial and antifungal properties, making it a candidate for use in applications that require the inhibition of microbial and fungal growth.
Used in Biological Research:
Due to its unique structure and functional groups, (2-amino-2-oxoethyl)(triphenyl)phosphonium chloride is employed in biological research to explore its interactions with biological systems and its potential applications in medicine and biotechnology.

Upstream product

• 603-35-0 triphenylphosphine 
• 79-07-2 Chloroacetamide 

Downstream Products

• 1426942-96-2 (E)-3-(5-bromo-2-nitrophenyl)acrylamide 
• 119930-84-6 3-(triphenyl-λ⁵-phosphanylidene)piperidine-2,6-dione 
• 58498-57-0 6-tert-butylpyridin-2(1H)-one 
• 28811-77-0 1.3.5-Tris-(cyclohexylcarbonyl)-benzol 
• 1159814-04-6 6-cyclohexylpyridin-2(1H)-one 
• 292825-75-3 2,6-dicyclohexylpyridine 
• 403517-92-0 triphenyl(thiocarbamoylmethylene)phosphorane 
• 38821-11-3 2-(triphenylphosphoranylidene)acetamide 

Relevant articles and documents

COMPOUNDS MODULATING PROTEIN RECRUITMENT AND/OR DEGRADATION

The invention provides cereblon binders for the degradation of proteins by the ubiquitin proteasome pathway for therapeutic applications.

A modular synthesis of teraryl-based α-helix mimetics, part 1: Synthesis of core fragments with two electronically differentiated leaving groups

Teraryl-based α-helix mimetics have proven to be useful compounds for the inhibition of protein-protein interactions (PPI). We have developed a modular and flexible approach for the synthesis of teraryl-based α-helix mimetics. Central to our strategy is the use of a benzene core unit featuring two leaving groups of differentiated reactivity in the Pd-catalyzed cross-coupling used for terphenyl assembly. With the halogen/diazonium route and the halogen/triflate route, two strategies have successfully been established. The synthesis of core building blocks with aliphatic (Ala, Val, Leu, Ile), aromatic (Phe), polar (Cys, Lys), hydrophilic (Ser, Gln), and acidic (Glu) amino acid side chains are reported. Turn on: Teraryl-based α-helix mimetics can be effectively produced by sequential Suzuki coupling of a central core fragment featuring electronically differentiated leaving groups with aryl boronic pinacol esters (see scheme; dppf=1,1′-bis(diphenylphosphino) ferrocene, DME=dimethoxyethane, Pin=pinacol, Tf=trifluoromethanesulfonyl). With a set of only 2×18 building blocks, all permutations of α-helix mimetics can be produced. Copyright

Syntheses of highly functionalised 6-substituted pteridines.

Methods for the synthesis of polyfunctional 6-substituted pteridines from the corresponding 6-aldehydes are described. Alkene, ester, ketone, amide, cyano, oxime, bromo, methoxy and dihydroxy functional groups have all been introduced principally through