25370-09-6

Basic information

• Product Name: Carbamic chloride, bis(phenylmethyl)-
• CAS NO: 25370-09-6
• Molecular Formula: C15H14ClNO
• Molecular Weight: 259.735
• Mol File: 25370-09-6.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Carbamic chloride, bis(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic chloride, bis(phenylmethyl)-(25370-09-6)
• EPA Substance Registry System: Carbamic chloride, bis(phenylmethyl)-(25370-09-6)

Safety Data

• Hazardous Substances Data: 25370-09-6(Hazardous Substances Data)

Upstream product

• 32315-10-9 bis(trichloromethyl) carbonate 
• 620-40-6 tribenzylamine 
• 2757-23-5 chloro(chlorosulfanyl)methanone 
• 103-49-1 dibenzylamine 
• 35517-91-0 N,N-Dibenzylthiocarbamoylchlorid 
• 75-44-5 phosgene 
• 503-38-8 trichloromethyl chloroformate 

Downstream Products

• 101584-40-1 ethyl dibenzylcarbamate 
• 35840-75-6 tetrabenzyl-oxalamide 
• 86548-82-5 1,1,3,3-tetrabenzylurea 
• 95835-70-4 dibenzynitramine 
• 5336-53-8 dibenzylnitrosamine 
• 19617-46-0 N,N,N'-tribenzylurea 
• 20002-24-8 dibenzylammonium nitrate 
• 100-52-7 benzaldehyde 
• 35929-26-1 N,N-bis(phenylmethyl)-propionamide 
• 23825-35-6 N,N-dibenzylbenzamide 
• 119163-15-4 (E)-N,N-dibenzyl-3-phenylprop-2-enamide 
• 180747-56-2 (N,N)-dibenzyl-3-phenylpropanamide 
• 637748-85-7 salicylaldehyde-N,N-dibenzyl semicarbazone 
• 1417342-97-2 [Re(CO)₃(HBnz₂)]₂ 

Relevant articles and documents

Rhenium(I) tricarbonyl complexes of salicylaldehyde semicarbazones: Synthesis, crystal structures and cytotoxicity

A series of N,N-disubstituted salicylaldehyde semicarbazones (SSCs), HOC6H4CHN-NHCONR2, and their rhenium(I) tricarbonyl complexes, [ReBr(CO)3(SSC)], have been synthesised and characterised by IR and 1H NMR spectroscopy. Crystallographic analysis of the complex [ReBr(CO)3(H2Bu2)] (H2Bu2 = SSC where R = Bun) showed that the SSC acts as a bidentate ligand via its imino nitrogen and carbonyl oxygen atoms. The [ReBr(CO)3(SSC)] complexes exhibit moderate to high cytotoxicities towards MOLT-4 cells (IC50 = 1-24 μM, cf. 18 μM for cisplatin), and the majority of them are virtually non-toxic against non-cancerous human fibroblasts. Apoptotic assays of [ReBr(CO) 3(H2Bnz2)] (Bnz = benzyl) revealed that it mediates cytotoxicity in MOLT-4 cells via apoptosis. The complex [ReBr(CO) 3(H2Bnz2)] reacts with guanosine by proton transfer from the phenolic OH group to N(7) of guanosine. In (CD 3)2SO, [ReBr(CO)3(H2Bnz 2)] undergoes facile conversion to the dimeric complex, [Re(CO) 3(HBnz2)]2, via bromide dissociation.

An improved one-pot cost-effective synthesis of N,N-disubstituted carbamoyl halides and derivatives

A convenient one-pot procedure is reported for preparing N,N-disubstituted carbamoyl chlorides by using chlorocarbonylsulfenyl chloride as a carbonylating agent. It comprises the reaction of secondary amines with chlorocarbonylsulfenyl chloride in the presence of an aprotic organic solvent to produce the corresponding N,N-disubstituted carbamoyl halides. Insertion of the carbonyl group without using phosgene is the novelty of this method.

Beta lactam compounds and their use as inhibitors of tryptase

Compounds of the formulas: are disclosed. These compounds inhibit tryptase as well as other enzyme systems or are selective tryptase inhibitors and are useful as antiinflammatory agents particularly in the treatment of chronic asthma.