25371-98-6

Basic information

• Product Name: 1-(4-TRIFLUOROMETHYLPHENYL)IMIDAZOLE
• Synonyms: 1-[4-(Trifluoromethyl)phenyl]-1H-imidazole;1-[4-(Trifluoromethyl)phenyl]imidazole 99%;1-[4-(Trifluoromethyl)phenyl]imidazole99%;1-(4-TRIFLUOROMETHYLPHENYL)IMIDAZOLE
• CAS NO: 25371-98-6
• Molecular Formula: C₁₀H₇F₃N₂
• Molecular Weight: 212.17
• Product Categories: Imidazol&Benzimidazole
• Mol File: 25371-98-6.mol
• Article Data: 58

Chemical Properties

• Melting Point: 71 °C
• Boiling Point: 90 °C
• Flash Point: 119.6 °C
• Appearance: /
• Density: 1.27 g/cm³
• Vapor Pressure: 0.00918mmHg at 25°C
• Refractive Index: 1.522
• PKA: 4.99±0.10(Predicted)
• CAS DataBase Reference: 1-(4-TRIFLUOROMETHYLPHENYL)IMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-TRIFLUOROMETHYLPHENYL)IMIDAZOLE(25371-98-6)
• EPA Substance Registry System: 1-(4-TRIFLUOROMETHYLPHENYL)IMIDAZOLE(25371-98-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 25371-98-6(Hazardous Substances Data)

Usage

General Description

1-(4-Trifluoromethylphenyl)imidazole is a chemical compound that belongs to the imidazole class of substances. Imidazoles are known for being versatile intermediates in organic synthesis. This particular chemical has a trifluoromethyl functional group attached to the phenyl ring, which is often used in medicinal chemistry due to its lipophilic properties, stability and bioavailability. Its CAS number is 2154-38-3. The physical and chemical properties, safety, toxicity, potential applications or uses of 1-(4-Trifluoromethylphenyl)imidazole in specific industries or research haven't been extensively studied or reported in literature as it's largely considered an intermediate for other chemical reactions.

InChI:InChI=1/C10H7F3N2/c11-10(12,13)8-1-3-9(4-2-8)15-6-5-14-7-15/h1-7H

Upstream product

• 288-32-4 1H-imidazole 
• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 98-56-6 4-chlorobenzotrifluoride 
• 455-13-0 4-Iodobenzotrifluoride 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 1201594-37-7 (4-[trifluoromethyl]phenyl) N,N-dimethylsulfamate 
• 34857-71-1 4-trifluoromethylphenyl N,N-diethylcarbamate 
• 402-45-9 4-hydroxybenzotrifluoride 

Downstream Products

• 1235961-86-0 [(1-(prop-2-ynyl)-3-(4-trifluoromethylphenyl))imidazolium] bromide 
• 1428261-69-1 C₁₁H₁₀F₃N₂⁽¹⁺⁾*I^(1-) 
• 1262662-74-7 [1-(2-pyridyl)methylene-3-(4-trifluoromethylphenyl)]imidazolium bromide 
• 444348-62-3 2-[(5-chloro-2-methoxyphenyl)methyl]-1-[4-(trifluoromethyl)phenyl]-1H-imidazole 

Relevant articles and documents

Core-shell Cu2S:NiS2@C hybrid nanostructure derived from a metal-organic framework with graphene oxide for photocatalytic synthesis of N-substituted derivatives

Recently, photocatalysis has attracted considerable interest, leading to opportunities for using renewable energy sources. A Cu:Ni metal-organic framework (MOF) modified with graphene oxide (GO) was fabricated by a facile and convenient process. Subsequen

Tuning the Copper(II)/Copper(I) Redox Potential for More Robust Copper-Catalyzed C–N Bond Forming Reactions

Complexes of copper and 1,10-phenanthroline have been utilized for organic transformations over the last 50 years. In many cases these systems are impacted by reaction conditions and perform best under an inert atmosphere. Here we explore the role the 1,1

Highly-efficient N-arylation of imidazole catalyzed by Cu(II) complexes with quaternary ammonium-functionalized 2-acetylpyridine acylhydrazone

The reaction of (E)-N,N,N-trimethyl-2-oxo-2-(2-(1-(pyridin-2-yl)ethylidene)hydrazinyl)ethan-1-aminium-chloride (HLCl) with copper(II) perchlorate led to mononuclear [CuLCl]ClO4 complex (1). The same reaction with excess of sodium azide gives di