254100-95-3

Basic information

• Product Name: TERT-BUTYL-N-SUCCINIMIDYL N N'-ETHYLENE-
• Synonyms: TERT-BUTYL-N-SUCCINIMIDYL N N'-ETHYLENE-
• CAS NO: 254100-95-3
• Molecular Formula: C12H19N3O6
• Molecular Weight: 301.297
• Product Categories: Carbonyl Compounds;Cyclic Imides;Organic Building Blocks
• Mol File: 254100-95-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 136-141 °C
• Appearance: /
• Storage Temp.: 2-8°C
• BRN: 8429708
• CAS DataBase Reference: TERT-BUTYL-N-SUCCINIMIDYL N N'-ETHYLENE-(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL-N-SUCCINIMIDYL N N'-ETHYLENE-(254100-95-3)
• EPA Substance Registry System: TERT-BUTYL-N-SUCCINIMIDYL N N'-ETHYLENE-(254100-95-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 10-21
• Hazardous Substances Data: 254100-95-3(Hazardous Substances Data)

Usage

Description

TERT-BUTYL-N-SUCCINIMIDYL N N'-ETHYLENE-, also known as tert-Butyl N-succinimidyl N,N′-ethylenedicarbamate, is a stable cyclic imide. It is a chemical compound with a unique structure that has potential applications in various industries due to its stability and reactivity.

Uses

Used in Pharmaceutical Industry:
TERT-BUTYL-N-SUCCINIMIDYL N N'-ETHYLENEis used as an intermediate compound for the synthesis of various pharmaceutical products. Its stability and reactivity make it a valuable component in the development of new drugs and medications.
Used in Chemical Synthesis:
In the field of chemical synthesis, TERT-BUTYL-N-SUCCINIMIDYL N N'-ETHYLENEis used as a key building block for creating more complex molecules. Its cyclic imide structure allows for further reactions and modifications, leading to the production of a wide range of chemical products.
Used in Research and Development:
TERT-BUTYL-N-SUCCINIMIDYL N N'-ETHYLENEis also utilized in research and development laboratories for studying its properties and potential applications. Its unique structure and reactivity make it an interesting subject for scientific investigation, which could lead to the discovery of new uses and applications in various industries.

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 284049-22-5 tert-butyl (2-isocyanatoethyl)carbamate 
• 3303-84-2 3-(tert-butyloxycarbonylamino)propionic acid 
• 39501-21-8 (2-azidocarbonyl-ethyl)-carbamic acid tert-butyl ester 

Downstream Products

• 1427038-70-7 C₂₉H₄₃N₇O₅ 

Relevant articles and documents

Helix-forming propensity of aliphatic urea oligomers incorporating noncanonical residue substitution patterns

Aliphatic N,N′-linked oligoureas are peptidomimetic foldamers that adopt a well-defined helical secondary structure stabilized by a collection of remote three-center H-bonds closing 12- and 14-membered pseudorings. Delineating the rules that govern helix formation depending on the nature of constituent units is of practical utility if one aims to utilize this helical fold to place side chains in a given arrangement and elaborate functional helices. In this work, we tested whether the helix geometry is compatible with alternative substitution patterns. The central -NH-CH(R)-CH2-NH-CO- residue in a model oligourea pentamer sequence was replaced by guest units bearing various substitution patterns [e.g., -NH-CH2-CH2-NH-CO-, -NH-CH2-CH(R)-NH-CO-, and -NH-CH(R1)-CH(R 2)-NH-CO-], levels of preorganization (cyclic vs acyclic residues), and stereochemistries, and the helix formation was systematically assessed. The extent of helix perturbation or stabilization was primarily monitored in solution by Fourier transform IR, NMR, and electronic circular dichroism spectroscopies. Our results indicate that although three new substitution patterns were accommodated in the 2.5-helix, the helical urea backbone in short oligomers is particularly sensitive to variations in the residue substitution pattern (position and stereochemistry). For example, the trans-1,2- diaminocyclohexane unit was experimentally found to break the helix nucleation, but the corresponding cis unit did not. Theoretical calculations helped to rationalize these results. The conformational preferences in this series of oligoureas were also studied at high resolution by X-ray structure analyses of a representative set of modified oligomers.

Effective preparation of O-succinimidyl-2(tert- butoxycarbonylamino)ethylcarbamate derivatives from β-amino acids. Application to the synthesis of urea-containing pseudopeptides and oligoureas

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