254114-95-9Relevant articles and documents
An asymmetric aminohydroxylation approach to the azepine core of (-)-balanol
Masse, Craig E.,Morgan, Adam J.,Panek, James S.
, p. 2571 - 2573 (2007/10/03)
(equation presented) An efficient formal synthesis of the potent protein kinase C inhibitor (-)-balanol that relies on a modified asymmetric aminohydroxylation of the α,β-unsaturated aryl ester (1) is reported. The aryl ester functionality and the dihydroquinyl alkaloid ligand system (DHQ)2-AQN are used to control the regio- and enantioselectivity of the process.