25413-27-8

Basic information

• Product Name: 3-(4-METHOXYPHENYL)PROPIONAMIDE
• Synonyms: 3-(4-METHOXYPHENYL)PROPIONAMIDE;3-(4-methoxyphenyl)propanamide
• CAS NO: 25413-27-8
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.22
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 25413-27-8.mol
• Article Data: 13

Chemical Properties

• Melting Point: 123-125 °C
• Boiling Point: 380.5 °C at 760 mmHg
• Flash Point: 210.2 °C
• Appearance: /
• Density: 1.095 g/cm³
• PKA: 16.51±0.40(Predicted)
• CAS DataBase Reference: 3-(4-METHOXYPHENYL)PROPIONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-METHOXYPHENYL)PROPIONAMIDE(25413-27-8)
• EPA Substance Registry System: 3-(4-METHOXYPHENYL)PROPIONAMIDE(25413-27-8)

Safety Data

• Hazardous Substances Data: 25413-27-8(Hazardous Substances Data)

Usage

General Description

3-(4-Methoxyphenyl)propionamide is a chemical compound with the molecular formula C10H13NO2. It is a white crystalline powder that is commonly used as a pharmaceutical intermediate. 3-(4-METHOXYPHENYL)PROPIONAMIDE is also known as 4-Methoxyphenyl-3-propionamide and is often used in the synthesis of various pharmaceutical drugs. It is important to handle this chemical with care, as it may be harmful if ingested, inhaled, or comes into contact with the skin. Additionally, it may cause irritation to the eyes, skin, and respiratory system.

Upstream product

• 5462-97-5 5-(4-methoxybenzylidene)-2-thioxo-4-thiazolidinone 
• 1929-29-9 3-(4-methoxyphenyl)propanoic acid 
• 15823-04-8 methyl 3-(4-methoxyphenyl)propionate 
• 15893-42-2 3-(4-methoxyphenyl)propionyl chloride 
• 36650-51-8 (2E)-3-(4-methoxyphenyl)acrylamide 
• 5720-07-0 4-methoxyphenylboronic acid 
• 79-06-1 2-propenamide 
• 943-89-5 (E)-3-(4-methoxyphenyl)acrylic acid 
• 830-09-1 3-(4'-methoxyphenyl)propenoic acid 
• 123-11-5 4-methoxy-benzaldehyde 
• 3901-07-3 3-(4-methoxy-phenyl)acrylic acid methyl ester 
• 121-97-1 4-Methoxypropiophenone 
• 36650-51-8 4-methoxycinnamic acid amide 
• 637-69-4 4-Methoxystyrene 

Downstream Products

• 55-81-2 4-Methoxyphenethylamine 
• 91247-71-1 2-4-methoxyphenylethylcarbamic acid methyl ester 
• 1158074-50-0 N-[1-(1H-1,2,3-benzotriazol-1-yl)-2,2-dimethylpropyl]-3-(4-methoxyphenyl)propanamide 
• 3791-75-1 2'-hydroxy-4,4',6'-trimethoxydihydrochalcone 
• 41350-95-2 1-(4-hydroxy-2,6-dimethoxy-phenyl)-3-(4-methoxy-phenyl)-propan-1-one 
• 1976-98-3 (4-hydroxyphenethyl)trimethylammonium iodide 
• 175287-92-0 N-(4-methoxy-phenethyl)-benzenesulfonamide 
• 119045-87-3 N-ethyl-p-tyramine 
• 857945-29-0 N-(4-hydroxyphenethyl)-N-methylacetamide 
• 871894-82-5 N-(4-methoxyphenethyl)-N-methylacetamide 
• 54815-19-9 N-(4-methoxyphenylethyl)acetamide 
• 370-98-9 N-methyltyramine 
• 82267-46-7 DL-2-amino-4-(p-methoxyphenyl)butanoic acid 
• 91337-83-6 3-(4-methoxy-phenyl)-propionaldehyde-semicarbazone 

Relevant articles and documents

Visible-Light Decatungstate/Disulfide Dual Catalysis for the Hydro-Functionalization of Styrenes

We describe an efficient photoredox system, relying on decatungstate/disulfide catalysts, for the hydrofunctionalization of styrenes. In this methodology the use of disulfide as a cocatalyst was shown to be crucial for the reaction efficiency. This photoredox system was employed for the hydro-carbamoylation, -acylation, -alkylation, and -silylation of styrenes, giving access to a large variety of useful building blocks and high-value molecules such as amides and unsymmetrical ketones from simple starting materials.

Visible light-mediated synthesis of amides from carboxylic acids and amine-boranes

Here, a photocatalytic deoxygenative amidation protocol using readily available amine-boranes and carboxylic acids is described. This approach features mild conditions, moderate-to-good yields, easy scale-up, and up to 62 examples of functionalized amides with diverse substituents. The synthetic robustness of this method was also demonstrated by its application in the late-stage functionalization of several pharmaceutical molecules.

Direct synthesis of amides from nonactivated carboxylic acids using urea as nitrogen source and Mg(NO3)2or imidazole as catalysts

A new method for the direct synthesis of primary and secondary amides from carboxylic acids is described using Mg(NO3)2·6H2O or imidazole as a low-cost and readily available catalyst, and urea as a stable, and easy to manipulate nitrogen source. This methodology is particularly useful for the direct synthesis of primary and methyl amides avoiding the use of ammonia and methylamine gas which can be tedious to manipulate. Furthermore, the transformation does not require the employment of coupling or activating agents which are commonly required.