25434-10-0Relevant articles and documents
Efficient Direct Halogenation of Unsymmetrical N -Benzyl- and N -Phenylureas with Trihaloisocyanuric Acids
Sanabria, Carlos M.,Costa, Bruno B. S.,Viana, Gil M.,De Aguiar, Lúcia C. S.,De Mattos, Marcio C. S.
, p. 1359 - 1367 (2017/12/26)
A simple and efficient methodology for the direct halogenation of N -phenylureas was developed using trihaloisocyanuric acids in acetonitrile at room temperature. This protocol proved to be effective for the construction of N -phenylureas with different patterns of substitution. Additionally, less reactive N -benzylureas were halogenated in the presence of a mixture of trifluoroacetic acid and acetonitrile at room temperature.
