25462-85-5

Basic information

• Product Name: 2-Chloro-6-methylpyridine-4-carboxylic acid
• Synonyms: TIMTEC-BB SBB005429;2-CHLORO-6-METHYLISONICOTINIC ACID;2-CHLORO-6-METHYLPYRIDINE-4-CARBOXYLIC ACID;2-CHLORO-6-PICOLINE-4-CARBOXYLIC ACID;BUTTPARK 43\57-36;2-CHLORO-6-METHYLPYRIDINE-4-CARBOXYLIC &;2-CHLORO-6-METHYLPYRIDINE-4-CARBOXYLIC ACID 95%;2-CHLORO-6-METHYLPYRIDINE-4-CARBOXYLIC ACID 95+%
• CAS NO: 25462-85-5
• Molecular Formula: C₇H₆ClNO₂
• Molecular Weight: 171.58
• EINECS: -0
• Product Categories: Pyridine;pharmacetical;Carboxylic Acids;Pyridines;Carboxylic Acids;pyridine series;Building Blocks;C7 to C18;C7 to C8;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;Heterocycle-Pyridine series
• Mol File: 25462-85-5.mol
• Article Data: 1

Chemical Properties

• Melting Point: 208-212 °C (dec.)(lit.)
• Boiling Point: 399 °C at 760 mmHg
• Flash Point: 195.1 °C
• Appearance: /
• Density: 1.39 g/cm³
• Vapor Pressure: 4.39E-07mmHg at 25°C
• Refractive Index: 1.578
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 3.07±0.10(Predicted)
• BRN: 122809
• CAS DataBase Reference: 2-Chloro-6-methylpyridine-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-6-methylpyridine-4-carboxylic acid(25462-85-5)
• EPA Substance Registry System: 2-Chloro-6-methylpyridine-4-carboxylic acid(25462-85-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-43-20/21/22
• Safety Statements: 26-36/37/39-22-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 25462-85-5(Hazardous Substances Data)

Usage

Chemical Properties

White solid

InChI:InChI=1/C7H6ClNO2/c1-4-2-5(7(10)11)3-6(8)9-4/h2-3H,1H3,(H,10,11)

Upstream product

• 3998-90-1 2-chloro-6-methyl-isonicotinic acid methyl ester 
• 30838-93-8 2-chloro-4,6-dimethyl-pyridine 
• 18619-97-1 3-cyano-6-methyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid ethyl ester 
• 86454-13-9 1,2-dihydro-6-methyl-2-oxo-4-pyridinecarboxylic acid 
• 98491-78-2 methyl 6-methyl-2-hydroxypyridine-4-carboxylate 

Downstream Products

• 109-06-8 α-picoline 
• 3998-90-1 2-chloro-6-methyl-isonicotinic acid methyl ester 
• 680569-51-1 1-methyl-1H-indole-2-carboxylic acid ((1S,2R)-2-{[(2-chloro-6-methyl-pyridin-4-ylmethyl)-cyano-methyl]-carbamoyl}-cyclohexyl)-amide 
• 3998-88-7 2-chloro-6-methylisonicotinic acid ethyl ester 
• 329946-08-9 2-chloro-N-methoxy-6,N-dimethylisonicotinamide 
• 26413-58-1 2-chloro-6-methyl-4-pyridinecarbonyl chloride 
• 4021-11-8 2-methylisonicotinic acid 
• 879222-13-6 [2-(3-chloro-benzyloxy)-6-methyl-pyridin-4-yl]-carbamic acid tert-butyl ester 
• 879222-14-7 2-(3-chlorobenzyloxy)-6-methylisonicotinamide 
• 158666-42-3 4-carbomethoxy-6,6'-bis(bromomethyl)-2,2'-bipyridine 
• 928306-84-7 4-(tert-butyldiphenylsilanyloxymethyl)-6,6'-dimethyl-2,2'-bipyridine N₁,N₁'-dioxide 
• 928306-83-6 4-(tert-butyldiphenylsilanyloxymethyl)-6,6'-dimethyl-2,2'-bipyridine 
• 1011264-34-8 2-chloro-6-methylisonicotinic acid (4-allyloxy-N-hydroxy-3,5-dimethylbenzamidine) ester 
• 879222-11-4 2-(3-chlorobenzyloxy)-6-methylisonicotinic acid 

Relevant articles and documents

Construction and functionalization of fused pyridine ring leading to novel compounds as potential antitubercular agents

A series of fused and functionalized pyridine derivatives were designed, synthesized and tested for their potential antitubercular properties. All these novel compounds were prepared by using multistep methods involving the construction of pyridine ring as a key synthetic step. Some of these compounds were found to be interesting when tested for their antitubercular properties in vitro and one of them appeared as an attractive and potential antitubercular agent.