254737-40-1Relevant articles and documents
Facile synthesis of α-substituted acrylate esters
Hin, Bunda,Majer, Pavel,Tsukamoto, Takashi
, p. 7365 - 7368 (2002)
Treatment of 5-monosubstituted Meldrum's acids with dimethylmethyleneimmonium iodide (Eschenmoser's iodide salt) in methanol gives α-substituted acrylate methyl esters in good yields. Easy access to 5-monosubstituted Meldrum's acids allowed us to synthesize a wide variety of α-substituted acrylate methyl esters. The reaction conditions are mild and tolerate many functional groups commonly used in organic synthesis; thus, this new method has potential as an alternative to conventional preparative methods for α-substituted acrylate esters.
Methods for treating anxiety, anxiety disorders and memory impairment using naaladase inhibitors
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, (2008/06/13)
The present invention relates to methods of using NAALADase inhibitors for treating glutamate-mediated diseases, disorders and conditions selected from the group consisting of anxiety, anxiety disorders and memory impairment.