25475-76-7

Basic information

• Product Name: THIOPHEN-3-AMINE HYDROCHLORIDE
• Synonyms: THIOPHEN-3-AMINE HYDROCHLORIDE;Thiophen-3-amine
• CAS NO: 25475-76-7
• Molecular Formula: C₄H₅NS*ClH
• Molecular Weight: 0
• Mol File: 25475-76-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: THIOPHEN-3-AMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: THIOPHEN-3-AMINE HYDROCHLORIDE(25475-76-7)
• EPA Substance Registry System: THIOPHEN-3-AMINE HYDROCHLORIDE(25475-76-7)

Safety Data

• Hazardous Substances Data: 25475-76-7(Hazardous Substances Data)

Usage

General Description

THIOPHEN-3-AMINE HYDROCHLORIDE is a chemical compound with the formula C4H5NS?HCl. It is a hydrochloride salt form of 3-aminothiophene, which is a heterocyclic aromatic compound containing a sulfur atom. THIOPHEN-3-AMINE HYDROCHLORIDE is commonly used in organic synthesis as a reagent, particularly in the preparation of various pharmaceuticals, agrochemicals, and other fine chemicals. It can also serve as a building block for the synthesis of other complex organic molecules. THIOPHEN-3-AMINE HYDROCHLORIDE is known for its reactivity and versatility, making it a valuable tool in organic chemistry research and industry.

Upstream product

• 1016552-72-9 3-aminothiophene-2-carboxylic acid hydrochloride 
• 17721-06-1 3-aminothiophene 
• 19228-91-2 tert-butyl 3-thienylcarbamate 

Downstream Products

• 70976-73-7 2-phenyl-thieno[3,2-d]thiazole 
• 116538-95-5 thieno[3,2-b]pyridine-6-carbonitrile 

Relevant articles and documents

A Scaffold-Hopping Strategy toward the Identification of Inhibitors of Cyclin G Associated Kinase

We recently reported the discovery of isothiazolo[4,3-b]pyridine-based inhibitors of cyclin G associated kinase (GAK) displaying low nanomolar binding affinity for GAK and demonstrating broad-spectrum antiviral activity. To come up with novel core structures that act as GAK inhibitors, a scaffold-hopping approach was applied starting from two different isothiazolo[4,3-b]pyridines. In total, 13 novel 5,6- and 6,6-fused bicyclic heteroaromatic scaffolds were synthesized. Four of them displayed GAK affinity with Kd values in the low micromolar range that can serve as chemical starting points for the discovery of GAK inhibitors based on a different scaffold.

SUBSTITUTED THIENOPYRIDONE COMPOUNDS WITH ANTIBACTERIAL ACTIVITY

Novel bicyclic heteroaromatic compounds are provided that are inhibitors of bacterial methionyl tRNA synthetase (MetRS). Compounds of the invention generally have a left hand side chroman group or left hand side tetrahydroquinoline group and a right hand