254878-95-0Relevant articles and documents
PRODRUGS AND MEDICAL USES THEREOF
-
Paragraph 024, (2019/12/25)
The invention relates to nitrogen mustards bearing substituted piperazine carboxamide and their corresponding pharmaceutically acceptable salts as cytotoxic agents that target tumours and methods of use thereof, alone or in combination with other cancer t
PIPERIDINE DERIVATIVES USEFUL AS GPR119 AGONISTS
-
Page/Page column 33, (2013/05/21)
Substituted piperidine compounds and pharmaceutically acceptable salts thereof are disclosed. Pharmaceutical compositions and methods of treatment are also included. The present invention relates to G-protein coupled receptor agonists. In particular, the present invention is directed to agonists of GPR 119 that are useful for the treatment of diabetes, especially type 2 diabetes, obesity, the metabolic syndrome and related diseases and conditions.
Development of a practical route for the manufacture of N-[5-(3-lmidazol-1-yl-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]acetamide
Hirt, Hans,Haenggi, Ruedi,Reyes, Jesus,Seeger-Weibel, Manuela,Gallou, Fabrice
, p. 111 - 115 (2012/12/31)
An efficient synthesis of a potent candidate in our respiratory program is described. The synthesis based on a key Darzens condensation-α,β- epoxide rearrangement circumvented the toxicity and safety issues encountered in the original synthesis route. Sub