254885-82-0Relevant articles and documents
Synthesis and hypoglycaemic activity of some new flavone derivatives. Part 1: Flavonylsulphonylurea derivatives
Bozdag, Oya,Verspohl, Eugen J.,Ertan, Rahmiye
, p. 435 - 438 (1999)
A new series of flavonyl-3'-sulphonylurea derivatives (1-7) was prepared by reaction of several isocyanates with flavone-3'-sulphonamide (III). The prepared compounds were tested for their insulinotropic activities in INS-1 cells. Compounds 1 and 4 were able to increase insulin release in the presence of 8.3 mM glucose at least at the higher concentrations used.
