25514-28-7 Usage
Description
Bruceolide is a quassinoid compound that can be isolated from the plants Brucea javanica and Brucea sumatrana. It has been demonstrated to possess significant antimalarial properties, making it a valuable substance in the search for effective treatments against malaria.
Uses
Used in Pharmaceutical Industry:
Bruceolide is used as an antimalarial agent for its ability to effectively combat the Plasmodium parasite, which is responsible for causing malaria. Its potent activity against the parasite makes it a promising candidate for the development of new drugs to treat this life-threatening disease.
Used in Research and Development:
In the field of research and development, Bruceolide serves as a valuable compound for studying the mechanisms of action against the Plasmodium parasite. This can lead to a better understanding of malaria and the development of novel therapeutic strategies to combat the disease.
Used in Drug Discovery:
Bruceolide's antimalarial properties make it a potential candidate for drug discovery, as it can be further studied and modified to create more effective and targeted treatments for malaria. Its unique structure and activity can also inspire the design of new drugs with improved efficacy and reduced side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 25514-28-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,5,5,1 and 4 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 25514-28:
(7*2)+(6*5)+(5*5)+(4*1)+(3*4)+(2*2)+(1*8)=97
97 % 10 = 7
So 25514-28-7 is a valid CAS Registry Number.
InChI:InChI=1/C21H26O10/c1-7-8-4-10-20-6-30-21(18(28)29-3,15(20)13(25)17(27)31-10)16(26)12(24)14(20)19(8,2)5-9(22)11(7)23/h8,10,12-16,23-26H,4-6H2,1-3H3/t8-,10+,12+,13+,14+,15+,16-,19-,20+,21-/m0/s1
25514-28-7Relevant articles and documents
Anti-malarial activities of acylated bruceolide derivatives
Murakarni, Nobutoshi,Umezome, Takashi,Mahmud, Taifo,Sugimoto, Masanori,Kobayashi, Motomasa,Wataya, Yusuke,Kim, Hye-Sook
, p. 459 - 462 (1998)
Several O-acylated derivatives of bruceolide (2) were synthesized and their anti-malarial activities together with selective toxicities were examined. It was found that 3,15-di-O-acetyl- (3c), 3,15-di-O-propionyl- (3d) and 15-O-propionylbruceolide (3b), as well as bruceine B (3a), exhibited potent anti-malarial activities with high selective toxicities.
