255391-09-4

Basic information

• Product Name: C₇H₇FN₂O₄S
• CAS NO: 255391-09-4
• Molecular Weight: 234.208
• Mol File: 255391-09-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₇H₇FN₂O₄S(CAS DataBase Reference)
• NIST Chemistry Reference: C₇H₇FN₂O₄S(255391-09-4)
• EPA Substance Registry System: C₇H₇FN₂O₄S(255391-09-4)

Safety Data

• Hazardous Substances Data: 255391-09-4(Hazardous Substances Data)

Upstream product

• 255391-08-3 C₇H₅ClFNO₄S 
• 39547-82-5 1-chloro-4-((fluoromethyl)sulfonyl)benzene 

Relevant articles and documents

Synthesis and in vitro antibacterial activity of 5-halogenomethylsulfonyl- benzimidazole and benzotriazole derivatives

A series of 5-halogenomethylsulfonylbenzimidazole and benzotriazole derivatives was synthesized as potential antibacterial agents. A new method of synthesis of benzimidazoles was developed. The antimicrobial activities of these compounds were tested against a series of reference and clinical strains. The reference strains include Gram-positive bacteria (S. aureus, S. epidermidis, B. subtilis, B. cereus, E. hirae, M. luteus) and Gram-negative rods (E. coli, P. vulgaris, P. aeruginosa, B. bronchiseptica). The clinical strains include six methicillin-resistant (MRSA) and two methicillin-sensitive (MSSA) S. aureus strains, one methicillin-resistant S. epidermidis, three E. faecalis and two E. faecium strains. Compound with trifluoromethyl- substituent at C-2 position (4) displayed significant antibacterial activities comparable with nitrofurantoin against four strains, and higher against Micrococcus luteus. MIC values for clinical Staphylococci strains (MRSA) were 12.5-25 μg/mL; for Enterococcus strains these values were 50-100 μg/mL. MIC values for reference and clinical strains of Staphylococcus and Enterococcus group were similar, respectively.