25563-13-7

Basic information

• Product Name: N-methoxy-3,4-dimethoxybenzamide
• Synonyms: N-methoxy-3,4-dimethoxybenzamide
• CAS NO: 25563-13-7
• Molecular Weight: 211.218
• Mol File: 25563-13-7.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: N-methoxy-3,4-dimethoxybenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-methoxy-3,4-dimethoxybenzamide(25563-13-7)
• EPA Substance Registry System: N-methoxy-3,4-dimethoxybenzamide(25563-13-7)

Safety Data

• Hazardous Substances Data: 25563-13-7(Hazardous Substances Data)

Upstream product

• 93-07-2 Veratric acid 
• 593-56-6 N-methoxylamine hydrochloride 
• 3535-37-3 3,4-dimethoxybenzoic acid chloride 

Downstream Products

• 55542-79-5 6,7-dimethoxy-3,4-diphenyl-1H-isochromen-1-one 
• 93-07-2 Veratric acid 
• 1444611-67-9 4-butyl-6,7-dimethoxy-3-phenylisoquinolin-1(2H)-one 
• 1444611-68-0 3-butyl-6,7-dimethoxy-4-phenylisoquinolin-1(2H)-one 
• 1404499-96-2 6,7-dimethoxy-3,4-diphenylisoquinolin-1(2H)-one 
• 1638642-73-5 C₂₅H₂₀F₃NO₄ 
• 1638642-70-2 2,6,7-trimethoxy-3,4-diphenylisoquinolin-1(2H)-one 
• 1638642-78-0 2,6,7-trimethoxy-4-(4-methoxyphenyl)-3-phenylisoquinolin-1(2H)-one 
• 1638642-75-7 3-(4-fluorophenyl)-2,6,7-trimethoxy-4-phenylisoquinolin-1(2H)-one 
• 1638642-71-3 2,6,7-trimethoxy-3,4-di-p-tolylisoquinolin-1(2H)-one 
• 2150-38-1 methyl 3,4-dimethoxybenzoate 
• 1202932-78-2 N,2,4,5-tetramethoxybenzamide 

Relevant articles and documents

Pd(II)-catalyzed annulation reactions of epoxides with benzamides to synthesize isoquinolones

Epoxides as alkylating reagents are unprecedentedly applied in Pd(II)-catalyzed C?H alkylation and oxidative annulation of substituted benzamides to synthesize isoquinolones rather than isochromans, which is accomplished through alerting the previously reported reaction mechanism by the addition of oxidant and TEA. Under these conditions, various isoquinolones have been prepared with yields up to 92%. In addition, this methodology has been successfully employed in the total syntheses of rupreschstyril, siamine, and cassiarin A in an expedient fashion.

Selective mono-alkylation of N-methoxybenzamides

We report our latest discovery of norbornene derivative modulated highly mono-selective ortho-C-H activation alkylation reactions on arenes bearing simple mono-dentate coordinating groups. The reaction features the use of readily available benzamides and alkyl halides. During the study, we prepared 30 mono-alkylated aryl amides in good yields with good mono-selectivity. We have also demonstrated that structurally rigid alkenes such as norbornene and its derivatives are a good class of ligand and could be used for future direct C-H functionalizations. The utilization of norbornene type ligands for assistance in C-H activation processes has opened a new window for future molecular design using direct C-H functionalization strategies.

Rhodium(iii)-catalyzed C-H/C-C activation sequence: Vinylcyclopropanes as versatile synthons in direct C-H allylation reactions

Succession of C-H activation and C-C activation was achieved by using a single rhodium(iii) catalyst. Vinylcyclopropanes were used as versatile coupling partners. Mechanistic studies suggest that the olefin insertion step is rate-determining and a facile β-carbon elimination is involved, which represents a novel ring opening mode of vinylcyclopropanes. This journal is