255712-65-3

Basic information

• Product Name: 5-chloro-1-phenoxycarbonyl-2-(thenoyloxy)indole
• Synonyms: 5-chloro-1-phenoxycarbonyl-2-(thenoyloxy)indole
• CAS NO: 255712-65-3
• Molecular Weight: 397.839
• Mol File: 255712-65-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-chloro-1-phenoxycarbonyl-2-(thenoyloxy)indole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-1-phenoxycarbonyl-2-(thenoyloxy)indole(255712-65-3)
• EPA Substance Registry System: 5-chloro-1-phenoxycarbonyl-2-(thenoyloxy)indole(255712-65-3)

Safety Data

• Hazardous Substances Data: 255712-65-3(Hazardous Substances Data)

Upstream product

• 17630-75-0 5-chloro-indolin-2-one 
• 197776-00-4 phenyl 5-chloro-2-[(phenoxycarbonyl)oxy]-1H-indole-1-carboxylate 
• 5271-67-0 2-Thiophenecarbonyl chloride 
• 197776-03-7 5-chloro-2-oxo-1-phenoxycarbonyl-2,3-dihydroindole 

Downstream Products

• 120210-48-2 tenidap 
• 255712-72-2 (Z)-5-chloro-3-[1-hydroxy-1-(2-thienyl)methylene]-2-oxo-1-phenoxycarbonyl-2,3-dihydroindole 

Relevant articles and documents

New routes to oxindole derivatives

A new, practical synthesis of the antirheumatic oxindole derivative, tenidap, has been elaborated. The new approach has initiated studies on the mechanism of the acylation reactions of oxindoles. Methods have been developed for the synthesis of 1-[alkoxy(or aryloxy)carbonyl]- and 1,3-di[alkoxy(or aryloxy)carbonyl]oxindoles starting from oxindoles. The route designed for tenidap has provided a facile access to several analogues, too. On another front, new reaction conditions are described, which turn Wenkert's synthesis of 3-alkyloxindoles (by Raney nickel induced alkylation of oxindoles with alcohols) into a highly efficient synthetic tool. The method has been extended to the synthesis of 3-alkyloxindoles from isatins and to the preparation of 3-(ω-hydroxyalkyl)oxindoles from oxindoles and isatins. Springer-Verlag 2004.