25617-34-9

Basic information

• Product Name: Propanamide, 2,2-dimethyl-N-[4-(trifluoromethyl)phenyl]-
• Synonyms: N-(4-trifluoromethylphenyl)-2,2-dimethylpropanamide;2,2-dimethyl-N-(4-trifluoromethylphenyl)propionamide;N-(4-(trifluoromethyl)phenyl)pivalamide;N-[4-(Trifluoromethyl)phenyl]-trimethylacetamide;4-trifluoromethyl-N-pivaloylaniline
• CAS NO: 25617-34-9
• Molecular Formula: C12H14F3NO
• Molecular Weight: 245.244
• Mol File: 25617-34-9.mol
• Article Data: 24

Chemical Properties

• CAS DataBase Reference: Propanamide, 2,2-dimethyl-N-[4-(trifluoromethyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanamide, 2,2-dimethyl-N-[4-(trifluoromethyl)phenyl]-(25617-34-9)
• EPA Substance Registry System: Propanamide, 2,2-dimethyl-N-[4-(trifluoromethyl)phenyl]-(25617-34-9)

Safety Data

• Hazardous Substances Data: 25617-34-9(Hazardous Substances Data)

Upstream product

• 455-14-1 4-trifluoromethylphenylamine 
• 598-98-1 Methyl pivalate 
• 3282-30-2 pivaloyl chloride 
• 144-55-8 sodium hydrogencarbonate 
• 754-10-9 2,2-dimethylpropionamide 
• 98-56-6 4-chlorobenzotrifluoride 
• 75-84-3 2,2-dimethyl-propanol-1 
• 630-19-3 pivalaldehyde 
• 75-98-9 Trimethylacetic acid 
• 1538-75-6 2,2-dimethylpropanoic anhydride 
• 887144-94-7 Togni's reagent II 
• 6625-74-7 N-pivaloylaniline 
• 62-53-3 aniline 
• 1548-13-6 p-trifluoromethyl-phenylisocyanate 

Downstream Products

• 180346-13-8 2'-[α-Hydroxy-(1-naphthyl)methyl]-4'-trifluoromethyl-2,2-dimethylpropionanilide 
• 117324-58-0 methyl 2-Amino-5-trifluoromethylbenzoate 
• 1233967-39-9 C₁₄H₁₃F₆NO₂ 
• 106746-81-0 N-[2-formyl-4-(trifluoromethyl)-phenyl]-2,2-dimethyl propanamide 
• 489429-73-4 1-(2-amino-5-(trifluoromethyl)phenyl)-2,2,2-trifluoroethanone 
• 1414889-30-7 C₁₈H₁₂F₆N₂O₂ 
• 1240490-45-2 (2-amino-5-trifluoromethylphenyl)-(5-chloro-2-methoxymethoxyphenyl)-[⁽¹⁴⁾C]methanone 
• 1240490-44-1 N-[2-(5-chloro-2-methoxymethoxy-[carbonyl-⁽¹⁴⁾C]benzoyl)-4-trifluoromethylphenyl]-2,2-dimethylpropionamide 
• 106746-83-2 2-(chloromethyl)-4-(trifluoromethyl)aniline hydrochloride 
• 106746-82-1 N-(2-Hydroxymethyl-4-trifluoromethyl-phenyl)-2,2-dimethyl-propionamide 

Relevant articles and documents

Equivalent Loading of Directed Arenes in Pd(II)-Catalyzed Oxidative Cross-Coupling of Aryl C-H Bonds at Room Temperature

The unsymmetrical biaryls (Ar1-Ar2) produced by the catalytic cross-couplings of aryl halides (Ar1-halo) with aryl metallics (Ar2-M) in the loading ratio of 1:1 are popular in chemical synthesis. In contrast, there has been less precedence on the same biaryls produced effectively from two normal aryl C-H bonds with equivalent loading. Here, we report that, in a palladium/oxidant/acid catalytic system at room temperature, one arene (Ar1-H, 1 equiv) can highly selectively couple with the other one (Ar2-H, 1 equiv) to afford the target Ar1-Ar2 just by controlling the directing groups and the substituted groups on their phenyl rings. The utility of this one-one cross-coupling is also demonstrated by synthesis of a few bioactive molecules.

Preparation method of 1-[3-chloro-5-(trifluoromethyl) phenyl]-2, 2, 2-trifluoroethanone and derivatives thereof

The invention relates to the field of synthesis of drug intermediates, in particular to a preparation method of 1-[3-chloro-5-(trifluoromethyl) phenyl]-2, 2, 2-trifluoroethanone and derivatives thereof, and the method comprises the following steps: synthe

General rhodium-catalyzed oxidative cross-coupling reactions between anilines: Synthesis of unsymmetrical 2,2′-diaminobiaryls

Described herein is a dual chelation-assisted RhCl3-catalyzed oxidative C-H/C-H cross-coupling reaction of aniline derivatives. The highlight of this methodology is the chemo- and regioselective cross-coupling between electronically similar substrates, which represents a highly challenging task in oxidative Ar-H/Ar-H cross-coupling reactions. Furthermore, this Cp?-free catalytic reaction tolerates a range of functional groups and requires only a low molar ratio of coupling partners. These features expedite the synthesis of unsymmetrical 2,2′-diaminobiaryls.